Henry Jackson

STUDIES OF DISEASES OF THE LYMPHOID AND MYELOID TISSUES

From a study of the metabolism of 71 lymph nodes and tumors one may conclude: 1. The nature of a tumor can not be predicted from the metabolism because too much overlapping of metabolic rates exists between the pathological groups. 2. There is no evidence metabolically one way or another as to whether malignant lymphomata of any type should be classed as neoplastic or as infectious processes. 3. The degree of cell differentiation can in most cases be foretold by the percentage difference between the aerobic and the anaerobic glycolysis. The greater the differentiation the greater the percentage difference. Sarcomata in general constitute an exception to this rule. 4. The degree of malignancy in carcinoma, but not in other tumors, can, with certain exceptions, be predicted from the height of the value U. 5. Human sarcomata appear to have a metabolism far more closely comparable to that of benign tumors than to that of carcinomata. They do not behave as malignant tumors under the Warburg classification. Their energy requirements are not of the same order as those of carcinoma. 6. One can not from the value U or from the glycolytic rates predict whether or not a tissue should be classed as neoplastic. 7. Warburgs findings for carcinomata are confirmed and amplified.

LII. A Comprehensive Study of Meningitis Secondary to Otitic or Sinus Infection

We shall analyze a group of 623 cases of meningitis other than meningococcic or tuberculous, stressing particularly the clinical aspeets. No attempt will be made to draw definite conclusions in regard to the question of vital importance, namely, the value of the different methods of treatment or prevention of meningitis secondary to ear or sinus infection. T able I presents a complete list of our cases of meningitis other than meningococcic or tuberculous. This list may be of general interest, although infections of the ear and sinuses are not conspicuous as etiologic factors in some of the rarer forms of meningitis. In nine instances among the mixed infections there was a history of a probable primary focus of infection. These are not of sufficient importance to be given in detail. In Table II are listed the conditions regarded as primary or as possible predisposing factors in the more common forms of purulent meningitis. This list is by no means complete, as a certain number of cases, particularly of sinusitis and mastoiditis, were undoubtedly undiagnosed. It is obvious that meningitis secondary to otitis media, mastoiditis or sinusitis, is most often due to the streptococcus. On the other hand, purulent meningitis secondary to respiratory infections is in most instances due to the pneumococcus and the influenza bacillus.

FIFTY CASES OF SCARLET FEVER.: Read before the Suffolk District Medical Society, Section for Clinical Medicine, Pathology and Hygiene, February 8, 1888.

I wish to present to the Section a short account of these cases, as an epidemic of this size always gives one an opportunity of making some interesting observations. These cases occurred in the North End of Boston during the months of April to October. Of these cases thirty may be characterized as of a mild type. Prodromal period short, usually twelve to twenty-four hours; vomiting almost always present; headache and malaise; usually more or less complaint of sore throat. In cases where an examination at the early stage was possible, I did not find the appearance of the throat sufficiently characteristic to warrant a diagnosis of scarlet fever merely from this symptom. In no case were convulsions seen. The period of efflorescence lasted from twenty-four hours to four days, rarely longer. Temperature not high. Many of the children wished to be about the house and were with difficulty kept