Herbert Halpaap

Cholesterol analogues with oxa- and oxa-aza side chain A novel class of inhibitors of cholesterol biosynthesis

Abstract The synthesis of neutral and basic monoethers of pregn-5-3-en-3β, 20α-diol, androst-5-en-3β, 17β-diol, androst-5-en-3β, 16β-diol, and of 20-aza-24-oxacholesterol is described. Saturated and chlorosubstituted derivatives of some of these compounds were prepared. 22-Oxa-25-azacholesterol and 20-oxa-21-nor-25-azacholesterol are potent inhibitors of cholesterol synthesis.