Herman Beerman

HYDATIDIFORM KERATINOUS CYST: CLINICAL RECOGNITION OF A BENIGIN PROLIFERATING EPIDERMOID CYST*

Attention is directed to the clinical recognition of early proliferative change in the lining of keratinous cysts. In the case reported, multiple small droplet excrescences could be observed on simple inspection. The term hydatidiform keratinous cyst is proposed as a designation for this distinctive clinical variant. Histologically it is to be distinguished from squamous cell epithelioma. It possibly represents an early clinically identifiable phase of the proliferative epidermoid cysts described by Wilson Jones (1966).

A specialty comes of age: innovative dermatological therapeutics in the twentieth century

Dermatology has reached its majority during the twentieth century as evidenced by the significant advances made in the understanding of skin diseases and their treatment [l]. Consequently, the discipline has been able to take its rightful place as a developed medical specialty. This was not always the case. The study of skin disease was often neglected. Therapy was primitive at best. The pioneers, such as Robert Willan (1751-1812) and Jean Louis Alibert (1768-1837) in the early 19th century and later in the era, Ferdinand von Hebra (1816-18801, Pierre Rayer (1793-18671, Erasmus Wilson (1809-1884) and Louis Duhring (1845-1913), were concerned with establishing what a cutaneous entitity was. Emphasis was frequently placed upon classification and morphology, for the founders of cutaneous medicine recognized that a successful therapeutic modality is decidedly dependent upon accurate diagnosis [2]. John Fordyce (1858-1929, the professor

A further study of the Kveim reaction in sarcoidosis and tuberculosis.

IN our experience, the Kveim reaction has not been a reliable aid in the diagnosis of sarcoidosis.1 , 2 Nevertheless, enthusiastic reports concerning its specificity continue to appear. James and T...

PENICILLIN THERAPY ALONE IN NEUROSYPHILIS: AN ANALYSIS OF CLINICAL RESULTS

Excerpt When we began the treatment of neurosyphilis with penicillin in November 1943, we determined to use penicillin alone without fever or arsenic or any other therapy which could influence the ...

Penicillin Treatment of Cardiovascular Syphilis

Evaluation of Treatment Among the still unsolved problems in the evaluation of penicillin therapy are: (1) uncertain criteria of diagnosis, clinical and post-mortem, of uncomplicated syphilitic aortitis; (2) influence of race and sex; (3) prophylactic effect; (4) amount of treatment adequate in early syphilis to prevent the development of cardiovascular complications. Furthermore, insufficient time has elapsed to determine the efficiency of penicillin in the management of cardiovascular syphilis. Evaluation of the effect of penicillin therapy on prognosis is also difficult because we do not know whether or not cardiovascular syphilis is changing with the passage of time, so that we are now seeing a different type of this phase of syphilis. The simultaneous occurrence in patients of cardiovascular and other forms of late syphilis, such as neurosyphilis, may alter the picture of therapeutic efficacy, besides increasing the potential reactivity of the patient to a particular treatment system or drug. Other variable factors involved are: the presence of diabetes mellitus; hypertension; degree of arteriosclerosis; renal function.

Retrovirus (HIV). Transfer, potential vectors, and biomedical concerns.

T Acquired Immune Deficiency Syndrome-Related Complex (ARC) is initiated by HTLV-III (LAV, HIV*), which, of itself, produces signs and neurologic symptoms as well as compromising the immune system so that opportunistic infections (those commonly AIDS-related) produce eventual fatalities. The AII3S virus is rapidly and exponentially spreading globally, with a recent estimate {Time, September 1986) of 10 million carriers and 100 thousand overt cases.