Herman L. Offerhaus

Passively Q-switched 0.1mJ fiber laser system at 1.53µm

We demonstrate a passively Q-switched fiber laser system generating pulses with as much as 0.1 mJ pulse energy at 1.53µm and > 1kHz repetition rate. This was achieved with a simple MOPA (master oscillator, power amplifier) scheme with a single pump source, realized with large mode area fiber and multiple reflections on a semiconductor saturable absorber mirror (SESAM).

High-energy, high-power ytterbium-doped Q-switched fiber laser

We report on a Q -switched, cladding-pumped, ytterbium-doped large-mode-area fiber laser operating at 1090 nm that is capable of generating 2.3 mJ of output pulse energy at a 500-Hz repetition rate and more than 5 W of average output power at higher repetition rates in a high-brightness beam (M(2) = 3) . Using a similar fiber with a smaller core, we generated >0.5-mJ pulses in a diffraction-limited beam. Our results represent a threefold increase in pulse energy over previously published values for Q-switched fiber lasers and firmly establish fiber lasers as compact, multiwatt, multimillijoule pulse sources with large scope for both industrial and scientific applications.

Characteristics of Q-switched cladding-pumped ytterbium-doped fiber lasers with different high-energy fiber designs

We theoretically and experimentally analyze Q-switched cladding pumped ytterbium-doped fiber lasers designed for high pulse energies. We compare the extractable energy from two high-energy fiber designs: (1) single- or few-moded low-NA large mode area (LMA) fibers and (2) large-core multimode fibers, which may incorporate a fiber taper for brightness enhancement. Our results show that the pulse energy is proportional to the effective core area and, therefore, LMA fibers and multimode fibers of comparable core size give comparable results. However, the energy storage in multimode fibers is mostly limited by strong losses due to amplified spontaneous emission (ASE) or even spurious lasing between pulses. The ASE power increases with the number of modes in a fiber. Furthermore, spurious feedback is more difficult to suppress with a higher NA, and Rayleigh back-scattering increases with higher NA, too. These effects are smaller in low-NA LMA fibers, allowing for somewhat higher energy storage. For the LMA fibers, we found that facet damage was a more severe restriction than ASE losses or spurious lasing. With a modified laser cavity, we could avoid facet damage in the LMA fiber, and reached output pulse energies as high as 2.3 mJ, limited by ASE. Theoretical estimates suggest that output pulse energies around 10 mJ are feasible with a larger core fiber, while maintaining a good beam quality.

High-energy single-transverse-mode Q-switched fiber laser based on a multimode large-mode-area erbium-doped fiber.

We demonstrate that appropriately designed doped multimode fibers provide robust single-mode output when used within a fiber laser cavity. Using a novel large-mode-area fiber, we demonstrate what we believe to be record single-mode (M(2) <1.2) pulse energies of >0.5 mJ from a Q -switched fiber laser and even higher pulse energies (as high as 0.85 mJ) with slightly compromised spatial-mode quality (M(2)<2.0) . This approach offers significant scope for extending the range of single-mode output powers and energies that are achievable from fiber-laser-amplifier systems.

Chemical Imaging of Oral Solid Dosage Forms and Changes upon Dissolution Using Coherent Anti-Stokes Raman Scattering Microscopy

Dissolution testing is a crucial part of pharmaceutical dosage form investigations and is generally performed by analyzing the concentration of the released drug in a defined volume of flowing dissolution medium. As solid-state properties of the components affect dissolution behavior to a large and sometimes even unpredictable extent there is a strong need for monitoring and especially visualizing solid-state properties during dissolution testing. In this study coherent anti-Stokes Raman scattering (CARS) microscopy was used to visualize the solid-state properties of lipid-based oral dosage forms containing the model drug theophylline anhydrate during dissolution in real time. The drug release from the dosage form matrix was monitored with a spatial resolution of about 1.5 microm. In addition, as theophylline anhydrate tends to form the less soluble monohydrate during dissolution, CARS microscopy allowed the solid-state transformation of the drug to be spatially visualized. The results obtained by CARS microscopy revealed that the method used to combine lipid and active ingredient into a sustained release dosage form can influence the physicochemical behavior of the drug during dissolution. In this case, formation of theophylline monohydrate on the surface was visualized during dissolution with tablets compressed from powdered mixtures but not with solid lipid extrudates.

Raman microscopy for cellular investigations – from single cell imaging to drug carrier uptake visualization

Progress in advanced therapeutic concepts requires the development of appropriate carrier systems for intracellular drug delivery. Consequently, analysis of interaction between carriers, drugs and cells as well as their uptake and intracellular fate is a current focus of research interest. In this context, Raman spectroscopy recently became an emerging analytical technique, due to its non-destructive, chemically selective and label-free working principle. In this review, we briefly present the state-of-the-art technologies for cell visualization and drug internalization. Against this background, Raman microscopy is introduced as a versatile analytical technique. An overview of various Raman spectroscopy investigations in this field is given including interactions of cells with drug molecules, carrier systems and other nanomaterials. Further, Raman instrumentations and sample preparation methods are discussed. Finally, as the analytical limit is not reached yet, a future perspective for Raman microscopy in pharmaceutical and biomedical research on the single cell level is given.

Shot noise limited heterodyne detection of CARS signals

We demonstrate heterodyne detection of CARS signals using a cascaded phase-preserving chain to generate the CARS input wavelengths and a coherent local oscillator. The heterodyne amplification by the local oscillator reveals a window for shot noise limited detection before the signal-to-noise is limited by amplitude fluctuations. We demonstrate an improvement in sensitivity by more than 3 orders of magnitude for detection using a photodiode. This will enable CARS microscopy to reveal concentrations below the current mMolar range.

A magnifying lens for velocity map imaging of electrons and ions

We have designed and implemented an electrostatic lens that magnifies the images of an existing velocity map imaging apparatus up to a factor of 20. The lens can be used to vary the magnification while keeping the field strength in the interaction region constant. For the region of interest where magnification is required (low energy ions or electrons, in a high external field) the lens does not add any observable aberrations to the imaging. We have characterized the performance of the lens using the imaging of slow photoelectrons.

Background free CARS imaging by phase sensitive heterodyne CARS

In this article we show that heterodyne CARS, based on a controlled and stable phase-preserving chain, can be used to measure amplitude and phase information of molecular vibration modes. The technique is validated by a comparison of the imaginary part of the heterodyne CARS spectrum to the spontaneous Raman spectrum of polyethylene. The detection of the phase allows for rejection of the non-resonant background from the data. The resulting improvement of the signal to noise ratio is shown by measurements on a sample containing lipid.

Application of a time-resolved event counting technique in velocity map imaging

We illustrate the use of a three-dimensional (x,y,t) charge-coupled-device (CCD) camera detection system in an ion imaging experiment. The time measurement is based on the decay characteristics of the phosphor screen, which is recorded in two successive images by a double exposure CCD camera. The strength of the method is illustrated in a velocity map imaging experiment on iodine molecules that are ionized and dissociated by intense femtosecond laser pulses. Singly and doubly charged iodine fragments are detected and their (x,y) coordinates and arrival time are recorded in an event counting routine. We estimate the time resolution of the system to be 1.3 ns. We show that the fragment velocity distribution derived from the (x,y,t) data is similar and in some conditions more accurate than the distribution obtained by a mathematical inversion of the (x,y) data only. This principle of detection can be used in all situations in which inversion methods are impossible, for example, when the particle distribution does not have an axis of symmetry.