Hermann Leying
Hoffmann-La Roche
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Featured researches published by Hermann Leying.
Journal of Clinical Virology | 2009
Sebastian Goedel; Matthias Rullkoetter; Sabrina Weisshaar; Carola Mietag; Hermann Leying; Florian Boehl
BACKGROUND Viral load quantification is established in the clinical management of chronic Hepatitis B virus (HBV) infection for assessing efficacies and resistance developments in anti-viral drug treatment. OBJECTIVES The fully automated COBAS AmpliPrep/COBAS TaqMan HBV Test, v2.0 was evaluated for the linear measuring range and the inclusivity of HBV genotype determination in EDTA plasma and serum samples. STUDY DESIGN Two kit lots of the test were used to determine the linear measuring range as well as linearity and limit of detection applying different concentration levels of specimens representing HBV genotypes A to H along with a pre-core mutant and the WHO Standard. RESULTS The COBAS AmpliPrep/COBAS TaqMan HBV Test, v2.0 displayed a linear measuring range of seven log(10) steps from 20IU/mL (lower limit of quantification) to 2.3E+08IU/mL (upper limit of quantification) yielding similar results for EDTA plasma and serum. Inclusivity was shown by reliable quantification of HBV genotypes A to H at different concentration levels. The >or=95% hit rate LOD was 15IU/mL for genotypes C, D, F, G, the pre-core mutant and the WHO Standard and 20IU/mL for genotypes A, B, E and H matching the tests lower limit of quantification. 95% PROBIT analysis yielded concentrations of 8.9IU/mL for the WHO Standard and of 6.0-16.4IU/mL for the genotypes. CONCLUSIONS The COBAS AmpliPrep/COBAS TaqMan HBV Test, v2.0 provides genotype inclusivity for accurate viral load monitoring in serum and EDTA plasma samples and supports clinical routine in the management of HBV infection.
Journal of Clinical Virology | 2006
S. Hochberger; D. Althof; R. Gallegos de Schrott; N. Nachbaur; H. Röck; Hermann Leying
Archive | 2004
Reiner Babiel; Norbert Franken; Hermann Leying; Judith Pinsl-Ober; Thomas Vess; Guenter Ziegler
Archive | 2007
Sigrid Adie; Hermann Leying; Nicole Nachbaur; Eberhard Russmann
Archive | 1996
Thomas Emrich; Hermann Leying; Matthias Hinzpeter; Gerlinde Karl
Archive | 2000
Hideji Tajima; Kimimichi Obata; Hermann Leying; Claus Bamberg; Volker Degenhardt
Archive | 1997
Hermann Leying; Matthias Hinzpeter; Hans-Peter Dipl Biol D Fritton; Clemens Dipl Biol Dr Doppler; Heiko Wittor
Archive | 1996
Hermann Leying; Matthias Hinzpeter; Heiko Wittor; Hans-Peter Dipl Biol D Fritton
Archive | 1999
Claus Bamberg; Volker Degenhardt; Hermann Leying; Kimimichi Obata; Hideji Tajima; バンベルク クラウス; デーゲンハルトゥ フォルカー; ライイング ヘルマン; 公道 小幡; 秀二 田島
Archive | 2011
Dirk Zimmermann; Hermann Leying