Hervé Bazin | Researchain

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Clinical Immunology and Immunopathology | 1984

Suppressive Effects of Anti-mu Serum On the Development of Collagen Arthritis in Rats

Simon M. Helfgott; Hervé Bazin; Alain Dessein; David E. Trentham

Sprague-Dawley rats were maintained in environmentally isolated conditions and some of them were injected beginning at birth with rabbit anti-mu serum to suppress B-cell maturation. All rats were subsequently immunized with chick type II collagen. Ten (28%) of 36 rats injected with anti-mu antiserum failed to develop serum hemagglutinating antibodies to collagen, and there was a significant (P less than 0.0003) reduction in the IgG-specific antibody titer to collagen in these 10 rats compared to the other 26 rats in this group. Only 1 (10%) of the antibody-suppressed rats developed arthritis compared to 20 (77%) of the 26 other rats in the anti-mu-treated group (P less than 0.001). Twenty-two (61%) of 36 immunized rats administered rabbit anti-ovalbumin serum and 14 (88%) of 16 immunized rats kept in the axenic conditions developed arthritis. Delayed-type hypersensitivity to collagen did not differ significantly between the groups. These data provide indirect evidence that antibodies play a role in the inception of collagen arthritis.

Transplantation Society. International congress | 1993

Xenotransplantation from pig to cynomolgus monkey: approach toward tolerance induction.

Dominique Latinne; Pierre Gianello; C Smith; Nickeleit; Tatsuo Kawai; M Beadle; C Haug; Megan Sykes; E Lebowitz; Hervé Bazin

Archive | 2001

Human monoclonal antibody directed against the influenza virus or a fragment thereof

Jacques Noury; Hervé Bazin; Dominique Latinne

Archive | 2001

Method for preparing a human monoclonal antibody, fragments thereof or antibodies comprising such fragments, resulting antibodies and use thereof

Jacques Noury; Hervé Bazin; Dominique Latinne

Archive | 2001

Procede de preparation d'un anticorps monoclonal humain, de fragments de celui-ci ou d'anticorps comprenant de tels fragments, les anticorps ainsi obtenus et leur utilisation

Jacques Noury; Hervé Bazin; Dominique Latinne

XVth World Congress of the Transplantation-Society | 1995

Endothelial and host mononuclear cell activation and cytokine expression during rejection of pig-to-baboon discordant xenografts.

Ba. Lesnikoski; Dominique Latinne; Da. Shaffer; Wj. Vanderwerf; Ap. Dalmasso; Mp. Soares; Hervé Bazin; Ww. Hancock; F.H Bach

International congress on xenotransplantation | 1994

Use of anti-mu monoclonal antibody as a therapeutic approach to achieve depletion of xenoreactive natural antibodies.

Miguel P. Soares; Françoise Nisol; F.H Bach; Hervé Bazin; Dominique Latinne

The F A S E B Journal | 1995

Perturbation of Cd2 Can Induce Alloantigen-specific Hyporesponsiveness in Naive T-cells

Vc. Giovinobarry; Dominique Latinne; Y. Xu; Rm. Glaser; Wm. Dickerson; T. Matejic; Bz. Schacter; Jl. Greenstein; Hervé Bazin; Me. Whitescharf; Rl. Monroy

Archive | 2001