Hervy E. Averette

Surgically defined prognostic parameters in patients with early cervical carcinoma: A multivariate survival tree analysis

This study was performed to identify a statistical combination of independent pathologic and clinical features that best predict 5‐year disease free survival (DFS) in patients with early stage cervical carcinoma treated by radical hysterectomy. The main goal of the study was to identify subsets of patients based on risk factors with maximal differences in DFS.

Prognostic Factors of Early Stage Cervical Cancer Treated by Radical Hysterectomy

Background. This study was performed to identify pathologic and clinical features that best correlate with lymph node metastasis and disease free survival among patients with Stage I and II cervical cancer treated by radical hysterectomy.

Detection, diagnostic evaluation and treatment of dysplasia and early carcinoma of the cervix

Dysplasia, in situ and early invasive carcinoma of the cervix are becoming an increasingly important part of the problem of cervical cancer. There is little doubt that the mounting fre quency with which these diagnoses are made is directly related to the in creased use of the Papanicolaou smear technique. We observed this in our own clinic over the past four years. Until 1966 only the women seen in Obstetrics and Gynecology had cervical smears done as a routine part of their exam inations. In the fall of 1966, thanks to a Public Health Service grant, cer vical cytologic screening was extended in an attempt to include all women ad mitted to the Kings County Hospital, a large municipal institution. The num ber of Stage 0 cases detected was in creased two and one-half times from 30 cases in 1966 to 78 cases in 1967. (Table 1.) The number of Stage I cases was increased by 50 percent. There can be no doubt that these changes resulted from the increase in screening. At the same time, a significant decrease in the

Evidence of tumor heterogeneity in cervical cancers and lymph node metastases as determined by flow cytometry

Background. The incidence and significance of tumor heterogeneity in primary tumors and metastatic lymph nodes were investigated in Stage IB–IIA cervical cancers.

Enhancement of progesterone receptor levels by interferons in AE‐7 endometrial cancer cells

Background. Interferon (IFN) has been reported to increase hormone receptor expression in breast cancer cells and to sensitize them to antiproliferative hormones. Endometrial cancer cells with high progesterone receptor (PR) level respond better to progesterone therapy than cells with either low or absent PR level. The effect of four different interferons (α and β, both natural [n] and recombinant [r]) on cell proliferation and steroid receptor levels was investigated in the PR positive AE‐7 human endometrial cancer cell line over a period of 12 days.