Herwandhani Putri

Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

OBJECTIVE To observe the combination effect of doxorubicin and Citrus hystrix (kaffir limes) peel ethanolic extract (ChEE) on blood serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity and cardio-hepato-histopathology of female Sprague Dawley rats. METHODS Doxorubicin and ChEE (5 rats per group) were administered in five groups of 3 rats each for 11 d. Group I: doxorubicin (dox) 4.67 mg/kg body weight; Group II: dox+ChEE 500 mg/kg body weight; Group III: dox+ChEE 1 000 mg/kg body weight; Group IV: ChEE 1 000 mg/kg body weight; Group V: untreated (control). RESULTS ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats, but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and AST. CONCLUSION ChEE has potency to be developed as cardioprotector agent in chemotherapy.

Current report of natural product development against breast cancer stem cells

Chemotherapeutic agents are commonly used as neoadjuvant for breast cancer therapy. However, there is evidence of treatment failure for most of patients due to acquired resistance. Cancer stem cells, a small population of cells within tumors, contribute to cancer resistance, tumor relapse, and metastasis. Therefore breast cancer stem cells-targeted therapy is a strategic way of overcoming chemoresistance. Some natural products have been identified to target breast cancer stem cells. This article aims to discuss the current report of preclinical studies of natural products i.e., phytochemicals, compound isolated from mushroom and alkaloid from the sponge that target breast cancer stem cells. This review does not only describe biological effects of natural products i.e., its effect on the signaling pathway, but also discuss chemical structure modification as well as recent pharmaceutical technology of natural products to target breast cancer stem cells. In conclusion, those natural products posses as novel therapeutic agents for breast cancer stem cells eradication and lead compound for the development of breast cancer stem cells-targeted drug.