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Dive into the research topics where Hesheng Zhang is active.

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Featured researches published by Hesheng Zhang.


Bioorganic & Medicinal Chemistry Letters | 2011

Stable and orally bio-available pro-drugs of CPS11

Aihong Huo; Hesheng Zhang; Yongbiao Guan; Guanghuai Zeng; Yingwei Chen; Xingwen Li

Stable and orally bio-available pro-drugs of CPS11 were synthesized. They are active on human umbilical vein endothelial cell proliferation assay and tube formation assay. The therapeutic efficacy and safety of 4 as a single agent or combined with Taxol in the treatment of MX-1 human breast cancer xenograft were evaluated. Compound 4 as a single agent failed to produce an anti-tumor activity, while it significantly enhanced antitumor potency of Taxol.


Archive | 2012

PHARMACEUTICAL COMPOSITIONS COMPRISING PYRIDYL CYANOGUANIDINE, PROCESS FOR PREPARING THE SAME AND USE THEREOF

Hesheng Zhang; Qinghua Zhang; Yingwei Chen; Aihong Huo


Archive | 2010

Pharmaceutical compositions containing pyridyl cyanoguanidines, preparation methods and uses thereof

Hesheng Zhang; Qinghua Zhang; Yingwei Chen; Aihong Huo


Archive | 2009

Salts of 3-(4-amino-1-oxo-1,3-dihydro-iso-indol-2-yl)piperdine-2,6-dione and derivatives thereof, polymorph of the salts, preparation and application thereof

Hesheng Zhang; Lijuan Ma; Xingwen Li; Guanghuai Zeng


Archive | 2012

PYRIDYL CYANOGUANIDINE DERIVATIVES

Hesheng Zhang; Xin Chen; Yingwei Chen; Junjie Cong; Xingwen Li


Archive | 2011

Dérivé de cyanoquinoline

Hesheng Zhang; Yingwei Chen; Qingchao He


Archive | 2010

Medicinal composition containing pyridyl cyanoguanidine as well as preparation and application thereof

Yingwei Chen; Aihong Huo; Hesheng Zhang; Qinghua Zhang


Archive | 2010

Dérivés de thiophène

Hesheng Zhang; 张和胜; Guanghuai Zeng; 曾广怀; Yifei Gao; 高鹥飞


Archive | 2010

Dérivés pyridyl cyanoguanidines

Hesheng Zhang; 张和胜; Xin Chen; 陈鑫; Yingwei Chen; 陈英伟; Junjie Cong; 从俊杰; Xingwen Li; 李幸稳


Archive | 2010

Thiophene[3,4-c]pyrrole pde4 mediators

Hesheng Zhang; Guanghuai Zeng; Yifei Gao

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Yongbiao Guan

Academy of Military Medical Sciences

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