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Heung Bae Jeon

Johns Hopkins University

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Publication

Featured researches published by Heung Bae Jeon.

The Journal of Steroid Biochemistry and Molecular Biology | 2004

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D3

Gary H. Posner; Kenneth R. Crawford; Hong Woon Yang; Mehmet Kahraman; Heung Bae Jeon; Hongbin Li; Jae Kyoo Lee; Byung Chul Suh; Mark A. Hatcher; Tanzina Labonte; Aimee R. Usera; Patrick M. Dolan; Thomas W. Kensler; Sara Peleg; Glenville Jones; Anqi Zhang; Bozena Korczak; Uttam Saha; Samuel S. Chuang

The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective inhibitor of the human 24-hydroxylase enzyme CYP24.

Steroids | 2004

Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D3 analog QW-1624F2-2: calcemic dose–response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry

Gary H. Posner; Heung Bae Jeon; Amy A. Narducci Sarjeant; Edward S. Riccio; Rupa S. Doppalapudi; Izet M. Kapetanovic; Uttam Saha; Patrick M. Dolan; Thomas W. Kensler

Based on an X-ray crystal structure determination, the A-ring stereochemistry of hybrid analog QW-1624F2-2 (1alpha-hydroxymethyl-16-ene-24,24-difluoro-25-hydroxy-26,27-bis-homovitamin D3) is revised to be 1alpha-CH2OH-3beta-OH. This analog is shown to be approximately 80-100 times less calciuric than the natural hormone 1alpha,25-dihydoxyvitamin D3. This analog is shown also to be non-genotoxic in three different standard assays.

Journal of Medicinal Chemistry | 2001

Antimalarial Simplified 3-Aryltrioxanes: Synthesis and Preclinical Efficacy/Toxicity Testing in Rodents

Gary H. Posner; Heung Bae Jeon; Michael H. Parker; Mikhail Krasavin; Ik Hyeon Paik; Theresa A. Shapiro

Journal of Medicinal Chemistry | 2002

Orally Active, Water-Soluble Antimalarial 3-Aryltrioxanes: Short Synthesis and Preclinical Efficacy Testing in Rodents

Gary H. Posner; Heung Bae Jeon; Poonsakdi Ploypradith; Ik Hyeon Paik; Kristina Borstnik; Suji Xie; Theresa A. Shapiro

Archive | 2002

Low-calcemic oxime analogs of 1α,25-dihydroxy vitamin D3

Gary H. Posner; Mehmet Kahraman; Heung Bae Jeon; Jay A. White; Glenville Jones; Bethany Halford

Bioorganic & Medicinal Chemistry | 2005

Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3

Gary H. Posner; Hyung-Jin Kim; Mehmet Kahraman; Heung Bae Jeon; Byung Chul Suh; Hongbin Li; Patrick M. Dolan; Thomas W. Kensler

Bioorganic & Medicinal Chemistry | 2006

Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3

Sandra Sinishtaj; Heung Bae Jeon; Patrick M. Dolan; Thomas W. Kensler; Gary H. Posner

Archive | 2003

25-SO2-substituted analogs of 1μ,25-dihydroxyvitamin D3

Gary H. Posner; Jae Kyoo Lee; Qiang Wang; Kenneth R. Crawford; Hong Woon Yang; Steven M. Silverman; Byung-Chul Suh; Jay A. White; Glenville Jones; Uttam Saha; Heung Bae Jeon

Tetrahedron | 2009

New A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: (2′-hydroxymethyl)tetrahydrofuro[1,2-a]-25-hydroxyvitamin D3

Heung Bae Jeon; Gary H. Posner

Archive | 2006

HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS

Gary H. Posner; Sandra Sinishtaj; Byung Chul Suh; Hyung-Jin Kim; Seong. H. Lee; Zhiyu Zhang; Heung Bae Jeon; Mehmet Kahraman; Hongbin Li; Kimberly S. Petersen

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Gary H. Posner

Johns Hopkins University

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Glenville Jones

Queen's University

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Byung Chul Suh

Johns Hopkins University

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Patrick M. Dolan

Johns Hopkins University

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Thomas W. Kensler

Johns Hopkins University

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Uttam Saha

Johns Hopkins University

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Mehmet Kahraman

University of Missouri

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Jay A. White

Queen's University

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Hong Woon Yang

Johns Hopkins University

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Hongbin Li

Johns Hopkins University

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