Hibiki Kanda

A retrospective analysis comparing the safety and efficacy of chemotherapy in elderly and non-elderly non-small-cell lung cancer patients.

Aim:  The number of elderly patients with non‐small‐cell lung cancer (NSCLC) is increasing in Japan. We retrospectively analyzed and compared the safety and efficacy of chemotherapy in elderly and non‐elderly NSCLC patients who received chemotherapy at Shimane University Hospital.

Successful treatment of severe bronchiectasis in the elderly using trimethoprim/sulfamethoxazole

ZBI found that the discontinuation of donepezil treatment resulted in improved BPSD and in a reduction of the caregivers’ burden related to FTD. These results suggest that donepezil given to patients with FTD can worsen BPSD and increase the burden on caregivers. Several limitations of the present study should be considered. First, the observation period in the present study was 2 weeks, which is quite short. Second, the study was open-label and had no control group. The present results therefore might be partially explained by the nocebo effect. Third, the sample population investigated might not represent the whole population of FTD patients, as patients were recruited from only one outpatient clinic. To overcome these limitations, we propose carrying out a 4-week blinded withdrawal study of donepezil in FTD patients using larger samples.