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Dive into the research topics where Hidechika Hashimura is active.

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Featured researches published by Hidechika Hashimura.


Digestion | 1989

Clinical and prognostic features of rectal sparing in ulcerative colitis

Nobuhide Oshitani; Atsuo Kitano; Shiro Nakamura; Akishige Obata; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Kiyotaka Okawa; Kenzo Kobayashi

Thirty patients with ulcerative colitis who had been followed clinically for more than 5 years were studied. Patients with total or left-sided colitis were investigated to evaluate the significance of rectal sparing in the prognosis of the disease. Patients were divided into two groups, one with complete or relative sparing of the rectum and the other with homogeneous lesions ranging from the rectum to the proximal colon based on endoscopic findings. The administration of topical corticosteroids seemed to have little effect on rectal sparing. However, the relapse index was significantly higher in patients with rectal sparing. The intractability index, representing the ratio of the duration of the active stage to the investigation period, was also higher, though not significantly so, in this group. The results suggest that rectal sparing may give information about intractability or a tendency to relapse.


Diseases of The Colon & Rectum | 1988

Immunoglobulin-containing cells in the colonic mucosa of rabbits with carrageenan-induced colitis

Takayuki Matsumoto; Atsuo Kitano; Nobuhide Oshitani; Akishige Obata; Masato Hiki; Hidechika Hashimura; Kiyotaka Okawa; Hiroshi Nagura; Kenzo Kobayashi

Immunohistochemical analysis of immunocompetent cells in the colonic mucosa was performed with carrageenan-induced experimental colitis in rabbits. Colitis was induced by seven months of oral administration of λ-degraded carrageenan following immunization with the same substances containing Freunds complete adjuvant. In the colonic mucosa with colitis, IgG- and IgM-containing cells were significantly increased in number (IgG: 540±94/mm2 in experimental group,vs. 120±54/mm2 in control,P<.05, IgM: 55.0±19.7/mm2 in experimental group,vs. 6.7±2.4/mm2 in control,P<.05). There was no significant increase of IgA-containing cells either in number or in proportion to the total mononuclear cells. These changes, induced by carrageenan in rabbits, had resembled those in human ulcerative colitis well. These observations suggested an impairment of the IgA-regualted local immune system and an abnormality in the differentiation process of immunoglobulin-secreting cells.


Diseases of The Colon & Rectum | 1986

The leading cord method of colonofiberscopy

Atsuo Kitano; Kiyotaka Okawa; Akishige Obata; Nobuhide Oshitani; Katsujiro Yoshiyasu; Masato Hiki; Takayuki Matsumoto; Hidechika Hashimura; Kenzo Kobayashi

Although the colonofiberscope has undergone various modifications and improvements, the insertion principle remains unchanged; that is pushing and rotation and the elasticity of the scope itself are inevitable. It often is difficult to maintain proper balance among these dynamic factors; imbalance prevents deep insertion. Over-elongation of the scope leads to insertion failure, particularly if there are adhesions of the sigmoid colon, overextension of the colon, or transverse colon ptosis. Our “leading cord” method is an excellent aid to colonofiberscopy. It can be inserted from the clamp hole of a conventional fiberscope and hardened to straighten the scope, thereby permitting deep insertion. With this technique the region from the rectum to the descending colon, as well as a ptosed transverse colon, can be straightened. Our clinical experience indicates that the rate of successful insertions in colonofiberscopy will be increased considerably with this complementary device.


Cancer Research | 1986

Epithelial Dysplasia of the Rabbit Colon Induced by Degraded Carrageenan

Atsuo Kitano; Takayuki Matsumoto; Masato Hiki; Hidechika Hashimura; Katsujiro Yoshiyasu; Kiyotaka Okawa; Shiro Kuwajima; Kenzo Kobayashi


Ensho | 1984

Studies of experimental ulcerative colitis induced by carrageenan in rabbits

Atsuo Kitano; Kenzo Kobayashi; Katsujiro Yoshiyasu; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Kiyotaka Okawa; Shiro Kuwajima


Nippon Daicho Komonbyo Gakkai Zasshi | 1991

A Study to Decrease the Ingested Volume of Polyethylene Glycol Electrolyte Lavage Solution (PEG) in Preparation for Colonoscopy

Kiyotaka Okawa; Atsuo Kitano; M. Tanimura; Akihiro Tabata; Makoto Obayashi; S. Nakamura; Akishige Obata; Nobuhide Oshitani; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; K. Kobayashi


Acta Gastro-Enterologica Belgica | 1989

THE EFFICACY OF POLYETHYLENE GLYCOL ELECTROLYTE LAVAGE SOLUTION (PEG) WITH SENNOSIDE AND METOCLOPRAMIDE (COMBINATION METHOD) VERSUS PEG ONLY (PEG METHOD) IN PREPARATION FOR COLONOSCOPY

Kiyotaka Okawa; Atsuo Kitano; Hiromu Okabe; Ryuji Hukushima; Kazutoshi Kashima; Shiro Nakamura; Akishige Obata; Nobuhide Oshitani; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Kenzo Kobayashi


Acta Gastro-Enterologica Belgica | 1991

TWO CASES OF RECTAL CROHN'S DISEASE

R. Fukushima; Atsuo Kitano; Hiromu Okabe; Kazutoshi Kashima; Shiro Nakamura; Akishige Obata; Nobuhide Oshitani; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Kiyotaka Okawa; Kenzo Kobayashi


Acta Gastro-Enterologica Belgica | 1991

ENDOSCOPIC FINDINGS OF TUBERCULOSIS THE ILEOCECAL REGION COMPARED TO THOSE CROHN'S DISEASE

Kiyotaka Okawa; Atsuo Kitano; Shiro Nakamura; Akishige Obata; Nobuhide Oshitani; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Yoshikazu Shindo; Hideaki Yamada; Shigeyoshi Harihara; Kenzo Kobayashi


Nippon Daicho Komonbyo Gakkai Zasshi | 1990

Clinical Evaluation of Childhood Onset Cases with Ulcerative Colitis

Hiromu Okabe; Atsuo Kitano; Nobuhide Oshitani; R. Fukushima; Kazutoshi Kashima; S. Nakamura; Akishige Obata; Hidechika Hashimura; Masato Hiki; Takayuki Matsumoto; Kiyotaka Okawa; K. Kobayashi

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