Hideki Komatsu

Agglutination assay of bladder cells by Concanavalin A proved the high susceptibility of analbuminemic rats to bladder carcinogens.

The susceptibility of analbuminemic rats, a mutant strain of Sprague-Dawley rats, to bladder carcinogens was examined by testing the agglutinability of isolated bladder epithelial cells by Concanavalin A (Con A). One-week treatment with 0.001% N-butyl-N-(4-hydroxybutyl)nitrosamine (BHBN) in the drinking water or 0.01% N-(4-(5-nitro-2-furyl)-2-thiazolyl)-formamide (FANFT), 0.01% and 0.1% 4-aminobiphenyl, 0.1% 4-nitrobiphenyl, 0.1% benzidine, 0.1% 2-napthylamine or 5% sodium saccharin in the diet clearly induced high agglutinability of bladder cells of male analbuminemic rats but not Sprague-Dawley rats. These results suggest that male analbuminemic rats are very susceptible to bladder carcinogens in general and therefore will be very useful in screening tests for bladder carcinogens.

A CASE OF BLADDER CANCER COMPLICATED WITH HYPERCALCEMIC CRISIS

A 76-year-old woman had bone metastasis after undergoing operation for a bladder cancer was urgently admitted to the hospital because of epigastric pain, general bone pain and unconsiousness on May 17, 1992. Abnormal high levels of blood calcium 14.2mg/dl and blood urea nitrogen 37mg/dl wee noted. The patient was diagnosied as hypercalcemic crisis. She was getting over the critical stage with administration of normal saline, frusemide and elcatonin. This paper presents the clinical course of this patient and some discussion on hypercalcemic crisis as oncologic emergency.