Hideki Nakagome

Carbonyl Compounds Generated from Electronic Cigarettes

Electronic cigarettes (e-cigarettes) are advertised as being safer than tobacco cigarettes products as the chemical compounds inhaled from e-cigarettes are believed to be fewer and less toxic than those from tobacco cigarettes. Therefore, continuous careful monitoring and risk management of e-cigarettes should be implemented, with the aim of protecting and promoting public health worldwide. Moreover, basic scientific data are required for the regulation of e-cigarette. To date, there have been reports of many hazardous chemical compounds generated from e-cigarettes, particularly carbonyl compounds such as formaldehyde, acetaldehyde, acrolein, and glyoxal, which are often found in e-cigarette aerosols. These carbonyl compounds are incidentally generated by the oxidation of e-liquid (liquid in e-cigarette; glycerol and glycols) when the liquid comes in contact with the heated nichrome wire. The compositions and concentrations of these compounds vary depending on the type of e-liquid and the battery voltage. In some cases, extremely high concentrations of these carbonyl compounds are generated, and may contribute to various health effects. Suppliers, risk management organizations, and users of e-cigarettes should be aware of this phenomenon.

Effect of YBCO-Coil Shape on the Screening Current-Induced Magnetic Field Intensity

A numerical simulation method which deals with the screening current-induced magnetic field for YBCO coils, including the self field effect induced by the transport current, has been developed. The simulation agrees well with the experimental results for an YBCO solenoid. Based on the numerical simulation, the effect of coil shape on the screening current-induced magnetic field intensity for the YBCO coils has been investigated. The field was demonstrated to reach a maximum if the solenoid corresponds to the minimum-volume design; it amounts to as large as -18% of the central magnetic field. Two major problems must be considered for YBCO coils regarding the screening current: (a) a reduction in the central magnetic field by the screening current and (b) a temporal drift of the apparent magnetic field due to relaxation of the screening current by flux creep. It is suggested that the latter can be suppressed by a current sweep reversal technique.

Magnitude of the Screening Field for YBCO Coils

Screening current induced in a YBCO-coated conductor coil causes two major problems; (i) reduction in the central magnetic field and (ii) temporal magnetic field drift due to flux creep. They constitute disadvantages for YBCO coil applications such as NMR, MRI, accelerator and high field magnets. The second problem is effectively suppressed by current sweep reversal, while the first remains unsolved. The present paper demonstrates that the screening current-induced magnetic field (screening field) is dominated by (a) the YBCO coil shape, (b) the YBCO-coated conductor width, (c) the coil inner diameter and (d) the ratio of operating current to the coil critical current. The dependence on these quantities is systematically investigated by numerical simulations. We conclude that coils with a smaller width of YBCO-coated conductor, a larger inner diameter and a higher ratio of operating current to the coil critical current generate a smaller central screening field ratio.

Operation of a 500 MHz high temperature superconducting NMR: towards an NMR spectrometer operating beyond 1 GHz.

We have begun a project to develop an NMR spectrometer that operates at frequencies beyond 1 GHz (magnetic field strength in excess of 23.5 T) using a high temperature superconductor (HTS) innermost coil. As the first step, we developed a 500 MHz NMR with a Bi-2223 HTS innermost coil, which was operated in external current mode. The temporal magnetic field change of the NMR magnet after the coil charge was dominated by (i) the field fluctuation due to a DC power supply and (ii) relaxation in the screening current in the HTS tape conductor; effect (i) was stabilized by the 2H field-frequency lock system, while effect (ii) decreased with time due to relaxation of the screening current induced in the HTS coil and reached 10(-8)(0.01 ppm)/h on the 20th day after the coil charge, which was as small as the persistent current mode of the NMR magnet. The 1D (1)H NMR spectra obtained by the 500 MHz LTS/HTS magnet were nearly equivalent to those obtained by the LTS NMR magnet. The 2D-NOESY, 3D-HNCO and 3D-HNCACB spectra were achieved for ubiquitin by the 500 MHz LTS/HTS magnet; their quality was closely equivalent to that achieved by a conventional LTS NMR. Based on the results of numerical simulation, the effects of screening current-induced magnetic field changes are predicted to be harmless for the 1.03 GHz NMR magnet system.

Generation of 24 T at 4.2 K using a layer-wound GdBCO insert coil with Nb3Sn and Nb–Ti external magnetic field coils

High-temperature superconducting (HTS) magnets are believed to be a practical option in the development of high field nuclear magnetic resonance (NMR) systems. The development of a 600 MHz NMR system that uses an HTS magnet and a probe with an HTS radio frequency coil is underway. The HTS NMR magnet is expected to reduce the volume occupied by the magnet and to encourage users to install higher field NMR systems. The tolerance to high tensile stress is expected for HTS conductors in order to reduce the magnet in volume. A layer-wound Gd–Ba–Cu–O (GdBCO) insert coil was fabricated in order to investigate its properties under a high electromagnetic force in a high magnetic field. The GdBCO insert coil was successfully operated at a current of up to 321 A and an electromagnetic force BJR of 408 MPa in an external magnetic field generated by Nb3Sn and Nb–Ti low-temperature superconducting coils. The GdBCO insert coil also managed to generate a magnetic field of 6.8 T at the center of the coil in an external magnetic field of 17.2 T. The superconducting magnet consisting of GdBCO, Nb3Sn and Nb–Ti coils successfully generated a magnetic field of 24.0 T at 4.2 K, which represents a new record for a superconducting magnet.

Operation of a 400 MHz NMR magnet using a (RE:Rare Earth)Ba2Cu3O7−x high-temperature superconducting coil: Towards an ultra-compact super-high field NMR spectrometer operated beyond 1 GHz

High-temperature superconductors (HTS) are the key technology to achieve super-high magnetic field nuclear magnetic resonance (NMR) spectrometers with an operating frequency far beyond 1GHz (23.5T). (RE)Ba2Cu3O7-x (REBCO, RE: rare earth) conductors have an advantage over Bi2Sr2Ca2Cu3O10-x (Bi-2223) and Bi2Sr2CaCu2O8-x (Bi-2212) conductors in that they have very high tensile strengths and tolerate strong electromagnetic hoop stress, thereby having the potential to act as an ultra-compact super-high field NMR magnet. As a first step, we developed the worlds first NMR magnet comprising an inner REBCO coil and outer low-temperature superconducting (LTS) coils. The magnet was successfully charged without degradation and mainly operated at 400MHz (9.39T). Technical problems for the NMR magnet due to screening current in the REBCO coil were clarified and solved as follows: (i) A remarkable temporal drift of the central magnetic field was suppressed by a current sweep reversal method utilizing ∼10% of the peak current. (ii) A Z2 field error harmonic of the main coil cannot be compensated by an outer correction coil and therefore an additional ferromagnetic shim was used. (iii) Large tesseral harmonics emerged that could not be corrected by cryoshim coils. Due to those harmonics, the resolution and sensitivity of NMR spectra are ten-fold lower than those for a conventional LTS NMR magnet. As a result, a HSQC spectrum could be achieved for a protein sample, while a NOESY spectrum could not be obtained. An ultra-compact 1.2GHz NMR magnet could be realized if we effectively take advantage of REBCO conductors, although this will require further research to suppress the effect of the screening current.

Development of cryogenic loop heat pipes

Since the loop heat pipe was invented in 1987 in Japan, efforts have been made to extend it for cryogenic use. In 1991, a loop heat pipe was demonstrated to work at liquid nitrogen temperature. The present work has taken these efforts still further. This work shows that loop heat pipes can be made to function at any cryogenic temperature, right down to 4 K. This was made possible because of the selection of heat pipe diameters based on the Laplace constant for the working fluid.

High Efficient two-Stage gm Refrigerator with Magnetic Material in the Liquid Helium Temperature Region

This paper describes experimental results obtained from a two-stage Gifford-McMahon (GM) refrigerator which uses a rare earth compound as a 2nd regenerator matrix instead of Pb (lead) matrix. The refrigeration capacity below 10 K for a conventional two-stage GM refrigerator is so small that the lowest temperature achieved is limited to the 8 K level. The purpose of this study is to improve the refrigeration performance in the temperature region below 10 K. The technical point is to use Er3Ni (Erbium-3 Nickel) as a 2nd stage regenerator matrix, because it has much larger volumetric specific heat than Pb below 15 K and has almost the same specific heat as Pb at higher temperature. The reciprocating speed was optimized to improve the refrigeration performance. Refrigeration capacity of 1 W at 6.59 K and no load temperature of 4.50 K were obtained from the Er3Ni regenerator. The refrigeration loss mechanism below 10 K is also discussed.

HTS-NMR: Present Status and Future Plan

Using high-Tc superconductors (HTS) is considered to be the only solution to dramatically increase the highest fields of NMR magnets because of their high critical fields. However, it is not easy to apply HTS to an NMR spectrometer (HTS-NMR) because a persistent-mode operation with HTS cannot satisfy the field stability of 0.01 ppm/h at present. To overcome this problem, we are now developing an HTS-NMR spectrometer in a driven-mode operation. As the first step, a layer-wound coil was fabricated with bronze-reinforced Bi-2223 conductors. Instead of the Nb3Sn coil, the Bi-2223 coil was installed as the innermost part of an existing NMR magnet. The magnet operated at a field of 11.7 T with a highly stabilized power supply. NMR measurements were carried out, and it was demonstrated that the quality of the multi-dimensional NMR spectra on the protein was equivalent to that obtained with a persistent-mode system. The next step will be to demonstrate its usefulness as a high-field NMR system. The upgrade of the 920 MHz NMR system installed at the Tsukuba Magnet Laboratory is underway. Its innermost coil is scheduled to be replaced by a Bi-2223 layer-wound coil for 2010. Its target field is 24.2 T (1.03 GHz).

Determination of Chemical Compounds Generated from Second-generation E-cigarettes Using a Sorbent Cartridge Followed by a Two-step Elution Method

We developed an analytical method for analyzing electronic cigarette (E-cigarette) smoke, and measured the carbonyl compounds and volatile organic compounds generated by 10 brands of second-generation E-cigarettes. A glass filter (Cambridge filter pad) for particulate matter and a solid sorbent tube packed with Carboxen-572 for gaseous compounds were used to collect E-cigarette smoke. These were then analyzed using a two-step elution method with carbon disulfide and methanol, followed by high-performance liquid chromatography (HPLC) and gas chromatography mass spectrometry (GC/MS). Formaldehyde (FA), acetaldehyde (AA), acetone (AC), acrolein (ACR), propanal (PA), acetol (AT), glyoxal (GO), and methyl glyoxal (MGO) were detected by HPLC in some E-cigarettes. Propylene glycol (PG), glycerol (GLY), and some esters were detected by GC/MS. GO and MGO exist mainly as particulate matter. AA, AC, ACR, PA, and AT exist mainly as gaseous compounds. FA exists as both particulate matter and gaseous compounds. These carbonyl compounds have carbon numbers C1 - C3. The main components of E-liquid are PG (C3) and GLY (C3). Therefore, the oxidation of liquids, such as PG and GLY in E-cigarettes upon incidental contact with the heating element in E-cigarette, is suggested as being a possible cause for carbonyl generation. When the puff number exceeds a critical point, carbonyl generation rapidly increases and then remains constant. The results of this study are now being used to determine the following E-cigarette smoking protocol: puff volume, 55 mL; puff duration, 2 s; and puff number, 30. E-cigarette analysis revealed very large variation in carbonyl concentration among not only different brands, but also different samples of the same product. Typical distributions of carbonyl concentration were not observed in any of the E-cigarettes tested, and the mean values greatly differed from median values.