Hideo Aoki

Serum prostaglandin levels in asthmatic patients

Levels of serum prostaglandins E and F were measured by radioimmunoassay in 40 asthmatic patients and healthy subjects. Levels of both prostaglandins--E and F--were significantly higher in asthmatic patients than in normal control subjects. The prostaglandin F/prostaglandin E ratio was significantly higher in asthmatic patients than in normal control subjects.

Prostaglandin-induced eosinopenia in splenectomized rats.

PGE1, PGE2, and PGF2alpha over a dose range of 1 to 50 microgram/kg decreased the number of circulating eosinophils in splenectomized rats. Pretreatment with a beta-blocking agent, propranolol, did not alter this effect, but adrenalectomy eliminated it. Anterior hypothalamic destruction also abolished eosinopenia induced by PGE1 and PGF2alpha but not that induced by PGE2.

A case of multiple myeloma complicated by liver abscess perforating into the stomach

62才の男性が右季肋部痛にて来院.諸検査にて典型的な多発性骨髄腫(IgG-κ型)が確認された. MCP療法にて38°C台の発熱は下熱し小康を得たが,その後再度発熱し心窩部に圧痛が出現した.エコー, CT等により肝膿瘍と診断し,ドレナージを行ない黄白色の膿汁をえた.細菌培養は陰性,諸種抗生物質治療にも抵抗性で,入院後32病日,麻痺性イレウスの状態で死亡した.剖検にて,回盲部原発のアメーバ性大腸炎と,腹腔内と胃に穿破したアメ一バ性肝膿瘍と判明した.多発性骨髄腫に合併したアメーバ性肝膿瘍の報告は本邦初であり,アメーバ性肝膿瘍自体まれな疾患であるが,今後一種の日和見感染として常に念頭におくべき疾患と考えられ報告した.