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Dive into the research topics where Hidetoshi Arimura is active.

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Featured researches published by Hidetoshi Arimura.


Journal of Biomaterials Science-polymer Edition | 2005

Preparation of a hyaluronic acid hydrogel through polyion complex formation using cationic polylactide-based microspheres as a biodegradable cross-linking agent

Hidetoshi Arimura; Tatsuro Ouchi; Akio Kishida; Yuichi Ohya

A novel hyaluronic acid (HA)-based hydrogel was prepared through polyion complex (PIC) formation between cationic polylactide (PLA)-based microspheres (MS+) and hyaluronic acid (HA−) as an anionic polyelectrolyte. The MS+ and HA formed a biodegradable PIC hydrogel (HA−/MS+) when mixed in aqueous media. The swelling behavior and mechanical properties of the PIC hydrogel could be controlled by changing the charge ratio between HA− and MS+. In addition, the HA−/MS+ PIC hydrogel resulted in a lower inflammatory response compared with a collagen hydrogel in vivo.


Biomacromolecules | 2005

Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer.

Hidetoshi Arimura; Yuichi Ohya; Tatsuro Ouchi


Macromolecular Rapid Communications | 2004

The Formation of Biodegradable Polymeric Micelles from Newly Synthesized Poly(aspartic acid)‐block‐Polylactide AB‐Type Diblock Copolymers

Hidetoshi Arimura; Yuichi Ohya; Tatsuro Ouchi


Journal of Polymer Science Part A | 2002

Synthesis of biodegradable amphiphilic AB-type diblock copolymers of lactide and depsipeptide with pendant reactive groups

Tatsuro Ouchi; Hidetake Miyazaki; Hidetoshi Arimura; Fumitaka Tasaka; Atsushi Hamada; Yuichi Ohya


Biomacromolecules | 2002

Preparation of poly(L-lactide)-based microspheres having a cationic or anionic surface using biodegradable surfactants.

Tatsuro Ouchi; Megumi Toyohara; Hidetoshi Arimura; Yuichi Ohya


Biomacromolecules | 2003

Synthesis of poly(L-lactide) end-capped with lactose residue

Tatsuro Ouchi; Tomoyuki Uchida; Hidetoshi Arimura; Yuichi Ohya


Macromolecular Bioscience | 2005

Thermosensitive biodegradable polydepsipeptide.

Yuichi Ohya; Megumi Toyohara; Mitsuhiro Sasakawa; Hidetoshi Arimura; Tatsuro Ouchi


Journal of Polymer Science Part A | 2002

Formation of Polymeric Micelles with Amino Surfaces from Amphiphilic AB-Type Diblock Copolymers Composed of Poly (Glycolic Acid Lysine) Segments and Polylactide Segments

Tatsuro Ouchi; Hidetake Miyazaki; Hidetoshi Arimura; Fumitaka Tasaka; Atsushi Hamada; Yuichi Ohya


Polymer | 2004

Preparation of poly[dl-lactide-co-glycolide]-based microspheres containing protein by use of amphiphilic diblock copolymers of depsipeptide and lactide having ionic pendant groups as biodegradable surfactants by W/O/W emulsion method

Tatsuro Ouchi; Mitsuhiro Sasakawa; Hidetoshi Arimura; Megumi Toyohara; Yuichi Ohya


Macromolecular Bioscience | 2003

Preparation of polylactide microspheres having positively or negatively charged surfaces

Hidetoshi Arimura; Yuichi Ohya; Tatsuro Ouchi; Hideaki Yamada

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Akio Kishida

Tokyo Medical and Dental University

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