Hideyuki Arai
Nagasaki University
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Featured researches published by Hideyuki Arai.
Acta Histochemica Et Cytochemica | 2011
Hideyuki Arai; Akira Furusu; Tomoya Nishino; Yoko Obata; Yuka Nakazawa; Masayuki Nakazawa; Misaki Hirose; Katsushige Abe; Takehiko Koji; Shigeru Kohno
Thalidomide is clinically recognized as a therapeutic agent for multiple myeloma and has been known to exert anti-angiogenic actions. Recent studies have suggested the involvement of angiogenesis in the progression of peritoneal fibrosis. The present study investigated the effects of thalidomide on the development of peritoneal fibrosis induced by injection of chlorhexidine gluconate (CG) into the mouse peritoneal cavity every other day for 3 weeks. Thalidomide was given orally every day. Peritoneal tissues were dissected out 21 days after CG injection. Expression of CD31 (as a marker of endothelial cells), proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), α-smooth muscle actin (as a marker of myofibroblasts), type III collagen and transforming growth factor (TGF)-β was examined using immunohistochemistry. CG group showed thickening of the submesothelial zone and increased numbers of vessels and myofibroblasts. Large numbers of VEGF-, PCNA-, and TGF-β-positive cells were observed in the submesothelial area. Thalidomide treatment significantly ameliorated submesothelial thickening and angiogenesis, and decreased numbers of PCNA- and VEGF-expressing cells, myofibroblasts, and TGF-β-positive cells. Moreover, thalidomide attenuated peritoneal permeability for creatinine, compared to the CG group. Our results indicate the potential utility of thalidomide for preventing peritoneal fibrosis.
Internal Medicine | 2016
Kenta Torigoe; Hideyuki Arai; Ayuko Yamashita; Yoshiaki Muraya; Yoko Obata; Tomoya Nishino
A 77-year-old man on maintenance dialysis developed hypotension, nausea and abdominal pain one hour after beginning to undergo hemodialysis. Abdominal computed tomography (CT) showed gas shadows in the intrahepatic portal vein and the small intestinal wall, but no signs indicating intestinal necrosis. Three days later, the gas shadows on abdominal CT disappeared by conservative therapy. In cases with both pneumatosis cystoides intestinalis and hepatic portal venous gas, intestinal necrosis should therefore be suspected and surgical therapy should also be considered, particularly in hemodialysis patients with a risk of intestinal ischemia. However, conservative therapy may be an option in cases with no intestinal necrosis.
Internal Medicine | 2010
Hisamitsu Miyaaki; Tatsuki Ichikawa; Naota Taura; Mio Yamashima; Hideyuki Arai; Yoko Obata; Akira Furusu; Hiroko Hayashi; Shigeru Kohno; Kazuhiko Nakao
Internal Medicine | 2013
Yuka Nakazawa; Tomoya Nishino; Atsushi Mori; Tadashi Uramatsu; Yoko Obata; Hideyuki Arai; Hideyuki Hayashi; Shoko Tsukasaki; Yoshiaki Muraya; Yuichi Inoue; Yoshihiro Yamamoto; Shigeru Kohno
Internal Medicine | 2012
Tomoya Nishino; Kana Minami; Tadashi Uramatsu; Yoko Obata; Hideyuki Arai; Noriho Sakamoto; Takashi Taguchi; Shigeru Kohno
Drugs in R & D | 2017
Satoru Oka; Yoko Obata; Kenta Torigoe; Miki Torigoe; Shinichi Abe; Kumiko Muta; Yuki Ota; Mineaki Kitamura; Satoko Kawasaki; Misaki Hirose; Tadashi Uramatsu; Hiroshi Yamashita; Hideyuki Arai; Hiroshi Mukae; Tomoya Nishino
Acta medica Nagasakiensia | 2017
Ayuko Yamashita; Hideyuki Arai; Kenta Torigoe; Yoshiaki Muraya; Masahiro Nakashima; Yoko Obata; Tomoya Nishino
CEN Case Reports | 2015
Kiyokazu Tsuji; Hideyuki Arai; Akira Furusu; Kenta Torigoe; Ayuko Tokuyama; Yoshiaki Muraya; Masahiro Nakashima; Takashi Taguchi; Yoko Obata; Tomoya Nishino; Shigeru Kohno
Internal Medicine | 2014
Akihiro Maekawa; Tadashi Uramatsu; Kana Minami; Yoko Obata; Hideyuki Arai; Takashi Taguchi; Yasushi Mochizuki; Masaharu Nishikido; Yoshiyuki Ozono; Tomoya Nishino; Shigeru Kohno
Acta Medica Nagasakiensia | 2013
Kana Minami; Tomoya Nishino; Hideyuki Arai; Misaki Hirose; Hiroshi Yamashita; Tadashi Uramatsu; Yoko Obata; Satoshi Funakoshi; Takashi Harada; Shigeru Kohno