Hikmet Hassa

Maternal blood clot patch therapy: A model for postamniocentesis amniorrhea☆☆☆★

Persistent amniorrhea and extraamniotic fluid collection was observed after amniocentesis. After the drainage of extraamniotic fluid, maternal blood was given under ultrasonographic guidance to produce a clot patch. Amniorrhea was controlled within 12 hours and a healthy baby was delivered at term.

Transdermal 17β-oestradiol in hormone replacement treatment after the menopause

SummaryCyclical treatment with transdermal 17β-oestradiol in patches and oral medroxyprogesterone acetate for four months was evaluated on 35 postmenopausal patients. Serum FSH and LH decreased (P<0-01) and serum oestradiol increased (P<0-05). In vaginal smears, parabasal cells decreased (P<005) and superficial cells increased (P<001).No changes were found in body weight, arterial blood pressure, urinary and vaginal culture results or serum Cortisol, bilirubin, fasting blood glucose, prothrombin time or activated partial thromboplastin time. The transdermal 17β-oestradiol delivery system is effective in the treatment of menopausal symptoms.