Hikmet Öz
Istanbul University
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Featured researches published by Hikmet Öz.
Toxicology | 1985
Gülçin Aykaç; Müjdat Uysal; A. Süha Yalçin; Necla Koçak-Toker; Ahmet Sivas; Hikmet Öz
Water containing 20% ethanol was given for a period of 3, 6 and 9 weeks to rats, and changes in hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferases were investigated. Lipid peroxide levels and glutathione peroxidase activities remained unchanged after 3 weeks and started to increase thereafter. Glutathione levels and glutathione transferase activities were significantly increased following ethanol consumption. These results show that chronic ethanol consumption stimulates hepatic lipid peroxidation in rats. This stimulation is not dependent on glutathione depletion and the increased glutathione peroxidase and glutathione transferase activities may reflect an adaptive change against ethanol-induced lipid peroxide toxicity.
Mechanisms of Ageing and Development | 1989
Müjdat Uysal; S. Seckin; Necla Koçak-Toker; Hikmet Öz
In recent years, the free radical theory of aging has attained great interest. Many studies on aging using tissue homogenates and subcellular fractions have provided evidence for the occurrence of lipid peroxidation. However, there are studies which report decrease or no significant change in parameters of lipid peroxidation. In our study, we investigated whether hepatic lipid peroxidation levels in male Swiss-Albino mice change with age. Three groups of animals, 3, 6 and 18 months old, were used. The diene conjugate and malondialdehyde levels of liver homogenates, mitochondria and microsomes were measured. Significant increases in both diene conjugate and malondialdehyde levels of liver homogenates and mitochondria have been observed in 18-month-old mice when compared with those aged 3 and 6 months. As for microsomes, only malondialdehyde levels were elevated in the old group when compared with young and adult groups. Both parameters were significantly increased in aged mice which indicate that lipid peroxidation is important in advancing age in mice.
Biochemical Medicine | 1985
Müjdat Uysal; Gülçin Aykaç; Necla Koçak-Toker; Ahmet Sivas; Yalçin S; Hikmet Öz
The effect of ingestion of water containing 20% ethanol for 1-2 months on lipid peroxide levels of liver, plasma, and erythrocyte was investigated in rats. Our results show that elevated plasma lipid peroxide levels and erythrocyte susceptibility to lipid peroxidation may reflect stimulated lipid peroxidation in rat liver following chronic ethanol ingestion.
Pharmacological Research | 1989
Gülçin Aykaç; Gül Özdemirler; Nilgün Alptekin; Nevin Arican; Buge Oz; Müjdat Uysal; Hikmet Öz
Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels.
Journal of Periodontology | 1993
Tahsin Unal; Erhan Firatli; Ahmet Sivas; Hasan Meriç; Hikmet Öz
Journal of Applied Toxicology | 1994
Gül Özdemirler; Gülçin Aykaç; Müjdat Uysal; Hikmet Öz
Journal of Applied Toxicology | 1989
Müjdat Uysal; Gül Özdemirler; Güldal Kutalp; Hikmet Öz
Journal of Clinical Periodontology | 1994
Erhan Firatli; Tahsin Unal; Nurcin Saka; Utku Onan; Ahmet Sivas; Hikmet Öz
Journal of Applied Toxicology | 1986
A. Süha Yalçin; Necla Koçak-Toker; Müjdat Uysal; Gülçin Aykaç; Ahmet Sivas; Hikmet Öz
Archive | 1990
Iberg N; Fluckiger R. Nonenzymatic; Ahmet Sivas; Tahsin Unal; Hikmet Öz