Hildur Einarsdottir

Computer-aided diagnosis of pulmonary diseases using x-ray darkfield radiography

In this work we develop a computer-aided diagnosis (CAD) scheme for classification of pulmonary disease for grating-based x-ray radiography. In addition to conventional transmission radiography, the grating-based technique provides a dark-field imaging modality, which utilizes the scattering properties of the x-rays. This modality has shown great potential for diagnosing early stage emphysema and fibrosis in mouse lungs in vivo. The CAD scheme is developed to assist radiologists and other medical experts to develop new diagnostic methods when evaluating grating-based images. The scheme consists of three stages: (i) automatic lung segmentation; (ii) feature extraction from lung shape and dark-field image intensities; (iii) classification between healthy, emphysema and fibrosis lungs. A study of 102 mice was conducted with 34 healthy, 52 emphysema and 16 fibrosis subjects. Each image was manually annotated to build an experimental dataset. System performance was assessed by: (i) determining the quality of the segmentations; (ii) validating emphysema and fibrosis recognition by a linear support vector machine using leave-one-out cross-validation. In terms of segmentation quality, we obtained an overlap percentage (Ω) 92.63  ±  3.65%, Dice Similarity Coefficient (DSC) 89.74  ±  8.84% and Jaccard Similarity Coefficient 82.39  ±  12.62%. For classification, the accuracy, sensitivity and specificity of diseased lung recognition was 100%. Classification between emphysema and fibrosis resulted in an accuracy of 93%, whilst the sensitivity was 94% and specificity 88%. In addition to the automatic classification of lungs, deviation maps created by the CAD scheme provide a visual aid for medical experts to further assess the severity of pulmonary disease in the lung, and highlights regions affected.

Grating-based X-ray tomography of 3D food structures

A novel grating based X-ray phase-contrast tomographic method has been used to study how partly substitution of meat proteins with two different types of soy proteins affect the structure of the formed protein gel in meat emulsions. The measurements were performed at the Swiss synchrotron radiation light source using a grating interferometric set-up.

Foreign Object Detection in Multispectral X-ray Images of Food Items Using Sparse Discriminant Analysis

Non-invasive food inspection and quality assurance are becoming viable techniques in food production due to the introduction of fast and accessible multispectral X-ray scanners. However, the novel devices produce massive amount of data and there is a need for fast and accurate algorithms for processing it. We apply a sparse classifier for foreign object detection and segmentation in multispectral X-ray. Using sparse methods makes it possible to potentially use fewer variables than traditional methods and thereby reduce acquisition time, data volume and classification speed. We report our results on two datasets with foreign objects, one set with spring rolls and one with minced meat. Our results indicate that it is possible to limit the amount of data stored to 50% of the original size without affecting classification accuracy of materials used for training. The method has attractive computational properties, which allows for fast classification of items in new images.