Hina Zafar

Synthesis and characterization of Schiff base octaazamacrocyclic complexes and their biological studies

A condensation reaction between 1,2-diphenylethane-1,2-dione dihydrazone (DPEDDH) and dimethyl or diethyloxalate in methanol resulted in a novel Schiff base octaazamacrocyclic ligand, (L): (6,7,14,15-tetraoxa-2,3,10,11-tetraphenyl-1,4,5,8,9,12,13,16-octaazacyclohexadecane-1,3,9,11-tetraene). Subsequently metal complexes of the type [MLX2] and [CuL]X2; (M=Mn(II), Co(II), Ni(II) and Zn(II); X=Cl or NO3) were synthesized by the reaction of the free macrocyclic ligand (L) with the corresponding metal salts in 1:1 molar ratio. These complexes were characterized on the basis of analytical data, molar conductivity and magnetic susceptibility measurements, ESI-mass, IR, NMR ((1)H and (13)C), EPR and electronic spectral studies. The thermal stability of the complexes was also studied by TGA and DTA analyses. These studies show that all the complexes have octahedral arrangement around the metal ions except copper complexes which are square planar. The ligand and its complexes were screened for their antibacterial activity in vitro against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria and were also studied for their anticancer activity against the human cancer cells lines: HeLa (Human cervical carcinoma), MCF7 (Human breast adenocarcinoma) and Hep3B (Human Hepatocellular carcinoma). The recorded IC50 values for the tested compounds show moderate to good cytotoxicity against these cancer cell lines. The copper complex, [CuL]Cl2, showed excellent antimicrobial activity against tested microorganisms which is almost equivalent to the standard drug ciprofloxacin.

Nanostructured coordination complexes/polymers derived from cardanol: “one-pot, two-step” solventless synthesis and characterization

Growing interests in the development of advanced functional materials from renewable resources due to the depleting petroleum resources, increasing costs, and associated hazards reflect global requirement for increased sustainability. Cardanol [Col] is an agro by-product of the cashew nut industry. It is cost effective, nontoxic, biodegradable and an abundantly available renewable resource. In the present study, we report the development of nanostructured coordination polymer [CP] self-standing transparent films from Col (as an organic linker or bridging-ligand) and Mn(II) ‘d5’ and Co(II) ‘d7’ divalent metal ions (as metal nodes) by a solid-state in situ method. The resulting CP films showed nanoporous morphology, amorphous behaviour, good thermal stability up to 260–300 °C, moderate antibacterial activity against Staphylococcus aureus (MTCC 902), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (MTCC 2453) and also good anti-biofilm activity.

Metal-Ion Directed Synthesis of 18-Membered Tetrathia Macrocyclic Complexes of Co(II), Ni(II), Cu(II), and Zn(II), Their Physicochemical Studies and DNA Binding Study of Copper Complex

18-membered tetrathia macrocyclic complexes of the type [MLX2], [M = Co(II), Ni(II), Cu(II), and Zn(II), X = Cl or NO3] have been synthesized by template condensation of α,α′-dibromo-o-xylene and 1,3-propanedithiol. The complexes have been characterized by elemental, ESI-mass, spectral (IR and NMR), molar conductance and magnetic susceptibility analysis. XRD has been used to deduce the morphology of the complex. The Absorption and fluorescence studies of Cu(II) complex show a significant binding to calf-thymus DNA. Among all composition, Cu(II) complex has showed crystalline behavior and significant binding with calf thymus DNA.

Vegetable Seed Oil Based Waterborne Polyesteramide: A “Green” Material

In present work we have taken an attempt to develop vegetable seed oil [VSO] based microwave assisted (green route) waterborne polyesteramide (zero toxicity), a green material. VSO based waterborne polyesteramide [WBPEA] was synthesized by simple route through microwave irradiation within 4–5 min by amidation and condensation of oil. The structure of the material was confirmed with the spectral techniques. The thermal degradation analysis of WBPEA by TGA showed that the polymer was stable up to 220°C, suitable for use as degradable “green polymeric material” for a variety of applications.