Hiroaki Nanba

Antitumor Activities of Edible Mushrooms by Oral Administration

Abstract Antitumor activities of edible mushrooms were investigated by breeding mice with the feed containing 10-30% (w/w) powdered fruit bodies. In allogeneic tumor systems (Sarcoma-180 in ICR mice), the tumor growth was suppressed to 40-50% by oral administration of edible mushrooms. While in syngeneic systems (B-16 melanoma or Lewis Lung carcinoma in C57BL/6, Meth-A fibrosarcoma in BALB/C), the feed containing Lentinus edodes (Shiitake) did not suppress the growth of all tumors, but the breeding with Grifola frondosa (Maitake) elongated the live time of mice to 145% in the case of Meth-A fibrosarcoma in BALB/C.