Hiroaki Taguchi

Amino Acids and Peptides. XLI. 1:2 Facile Synthesis of 5-Methyl-2(1H)- pyrazinone Derivatives from Dipeptidyl Chloromethyl Ketones 3

Abstract 5-Methyl-2(1 H )-pyrazinone derivatives were easily synthesized by short reflux of dipeptidyl chloromethyl ketone hydrochlorides in MeOH.

Simple approach towards the synthesis of 5-methyl-2-hydroxypyrazine derivatives from dipeptidyl chloromethyl ketones

Abstract 5-Methyl-2-hydroxypyrazine derivatives were easily synthesized by short reflux of dipeptidyl chloromethyl ketone hydrochlorides in MeOH.

Total synthesis of optically active deoxyaspergillic acid from dipeptidyl aldehyde

Abstract Optically active deoxyaspergillic acid was easily synthesized by a newly developed procedure for preparation of 2(1 H )-pyrazinone derivatives from l -leucyl- l -isoleucine aldehyde hydrochloride (H- l -Leu- l -Ile-H·HCl).

Amino Acids and Peptides. Part 48. 1 Studies on the Structure of an Unexpected Reaction Product from Dipeptidyl Chloromethyl Ketone during Acid Hydrolysis 2

During the course of the synthesis of peptidyl nchloromethyl ketones (CMKs), it was revealed that amino acid nrecovery after acid hydrolysis (6 mol dm n -3 n HCl, n110 °C, 20 h) of dipeptidyl chloromethyl ketones was markedly nlow (7.1–33.7%) owing to the formation of n5-methylpyrazin-2(1H)-one derivatives during the acid nhydrolysis.