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Dive into the research topics where Hiroaki Yanagisawa is active.

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Featured researches published by Hiroaki Yanagisawa.


Tetrahedron Letters | 1981

Stereocontrolled syntheses of chiral intermediates of thienamycin from threonines

Masao Shiozaki; Noboru Ishida; Tetsuo Hiraoka; Hiroaki Yanagisawa

Abstract Both stereospecific and stereoselective syntheses of thienamycin intermediates which have the correct configurations at the three contiguous chiral centers are reported.


Tetrahedron Letters | 1983

Synthesis of optically active azetidin-2-ones from L-threonine

Hiroaki Yanagisawa; Akiko Ando; Masao Shiozaki; Tetsuo Hiraoka

Abstract 3S-(1R-Hydroxyethyl)-4R-phenylsulfonylazetidin-2-one derivative was synthesized from L-threonine in an 8-step process including the novel transformation of the oxirane ring to the azetidin-2-one.


Tetrahedron Letters | 1982

Conversion of cepham-1-oxide into 1-oxadethiacepham

Hiroaki Yanagisawa; Akiko Ando

Abstract 3-Exomethylenecepham-1-oxides 1 were converted into the 3-exomethylene-1-oxadethiacepham in three step process including the novel bond cleavage of the tetrahydrothiazine ring of 1 with 2-mercaptobenzothiazle or 2-mercapto-benzoxazole.


The Journal of Antibiotics | 1987

STUDIES ON ORALLY ACTIVE CEPHALOSPORIN ESTERS

Koichi Fujimoto; Sadao Ishihara; Hiroaki Yanagisawa; Junya Ide; Ejji Nakayama; Hideo Nakao; Shinichi Sugawara; Masayuki Iwata


Bulletin of the Chemical Society of Japan | 1970

Synthesis of Cyclic α-Amino Acids. IV. Syntheses of Adenine Nucleosides of 3-Amino-3-C-carboxy-3-deoxy-D-ribofuranose and 3-Amino-3-C-carboxy-3-deoxy-D-ribopyranose

Hiroaki Yanagisawa; Mitsuhiro Kinoshita; Saburo Nakada; Sumio Umezawa


The Journal of Antibiotics | 1976

A new semisynthetic 7.ALPHA.-methoxycephalosporin, CS-1170. 7.BETA.-(((cyanomethyl)thio)acetamido)-7.ALPHA.-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid.

Hideo Nakao; Hiroaki Yanagisawa; Bunji Shimizu; Masakatsu Kaneko; Mitsuo Nagano; Shinichi Sugawara


Tetrahedron Letters | 1976

A novel simple synthesis of 7α-substituted cephalosporins

Hiroaki Yanagisawa; Masami Fukushima; Akiko Ando; Hideo Nakao


Tetrahedron Letters | 1975

A novel general method for synthesizing 7α-methoxycephalosporins

Hiroaki Yanagisawa; Masami Fukushima; Akiko Ando; Hideo Nakao


Bulletin of the Chemical Society of Japan | 1967

The Synthesis of Cyclic α-Amino Acids. II

Mitsuhiro Kinoshita; Hiroaki Yanagisawa; Shuhei Doi; Eisuke Kaji; Sumio Umezawa


The Journal of Antibiotics | 1976

Synthesis of 7alpha-substituted cephalospofins. V4 Novel oxidation procedure for syntheses of 7alpha-methoxycephalosporins and 6alpha-methoxypenicillins.

Hiroaki Yanagisawa; Masami Fukushima; Akiko Ando; Hideo Nakao

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