Hiroharu Suzuki

Membranous Glomerulonephritis Associated with Diffuse Malignant Pleural Mesothelioma: Report of a Case

Abstract Membranous glomerulonephritis is associated with a variety of malignant neoplasms. However, an association between membranous glomerulonephritis and pleural mesothelioma is very rare. We report herein a case of pleural mesothelioma associated with membranous glomerulonephritis. A 52-year-old man with severe proteinuria was diagnosed to have diffuse malignant pleural mesothelioma. A left extrapleural pneumonectomy was thus performed. The proteinuria resolved postoperatively. However, 6 months postoperatively, the proteinuria recurred. A renal biopsy revealed membranous glomerulonephritis. Simultaneously, a recurrence of the mesothelioma in the left pleural cavity was confirmed. Although rare, membranous glomerulonephritis appears to be one type of paraneoplastic syndrome associated with malignant pleural mesothelioma.

The Concomitant Effects of Cis-diamminedichloroplatinum and Caffein on the Proliferation and Chromosomal Changes.

ヒト胃癌細胞株STKM-1を用いてCis-diamminedichloroplatinum (以下CDDP) とカフェイソとの併用抗腫瘍効果と染色体におよぼす影響について検討した.CDDP (2μg/ml) 3時間接触で57%の増殖率であったが, CDDP接触後カフェイソ1mM持続接触にて23%に, 2mMにて9.3%に低下し, 抗腫瘍効果の増強が認められた.CDDP (2μg/ml) 処理後の染色体におけるgap/breakの出現頻度は1.816±1.509/Cell, exchangeの出現頻度は0.184±0-565/Ce11であった.CDDP処理直後からカフェイン1mMを24時間接触させるとgap/breakの出現頻度は4-206±3.162/Cell, exchangeは0.760±0.938/Cellと増加した.CDDP処理後24, 48時間後にカフェインを接触させても同様の結果が得られた.以上より, カフェインはDNA修復阻害作用を有し, 胃癌に対する化学療法において, CDDPとの併用で抗腫瘍効果の増強が期待された.