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Hirokazu Makita

Gifu Pharmaceutical University

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Publication

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Chemical & Pharmaceutical Bulletin | 1986

Suitable Size of Preparations to Evaluate the Bioavailability of Enteric-Coated Preparations by the Use of Gastric-Acidity-Controlled Rabbits

Terutaka Takahashi; Masaaki Mori; Yuko Uezono; Hirokazu Makita; Yutaka Nakanishi; Yu Imasato

The limiting size of enteric-coated preparations for which it is possible to evaluate the bioavailability by using gastric-acidity-controlled rabbits (GAC-rabbits) was investigated. Entericcoated preparations with different diameters were administered to GAC-rabbits, and drug bioavailability from each preparation was evaluated. In the case of enteric-coated granules, there was no problem in evaluating the bioavailability. However, in the case of enteric-coated tablets, the maximum size for which it was possible to evaluate the bioavailability was 4.1mm in diameter. The results indicate that the use of GAC-rabbits in bioavailability studies of enteric-coated preparations is restricted by the size of the preparations.

Archive | 1990

Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked

Yoshimi Shirai; Kiyomi Sogo; Yoshihiko Nakamura; Hiroshi Fujioka; Hirokazu Makita

Biological & Pharmaceutical Bulletin | 1993

A Novel Fine Granule System for Masking Bitter Taste

Yoshimi Shirai; Kiyomi Sogo; Kazumitsu Yamamoto; Kenji Kojima; Hiroshi Fujioka; Hirokazu Makita; Yasuhiko Nakamura

Chemical & Pharmaceutical Bulletin | 1990

Particle Design of Enoxacin by Spherical Crystallization Technique. I. : Principle of Ammonia Diffusion System (ADS)

Masumi Ueda; Yasuhiko Nakamura; Hirokazu Makita; Yu Imasato; Yoshiaki Kawashima

Chemical & Pharmaceutical Bulletin | 1989

Influence of specific gravity and food on movement of granules in the gastrointestinal tract of rats.

Masaaki Mori; Yoshimi Shirai; Yuko Uezono; Terutaka Takahashi; Yasuhiko Nakamura; Hirokazu Makita; Yutaka Nakanishi; Yu Imasato

Chemical & Pharmaceutical Bulletin | 1985

Movement of granules and tablets in the gastrointestinal tract of gastric-emptying-controlled rabbits.

Terutaka Takahashi; Yoshimi Shirai; Yasuhiko Nakamura; Yuko Uezono; Hirokazu Makita; Yutaka Nakanishi; Yu Imasato

Journal of The Society of Powder Technology, Japan | 1991

Studies of Nondisintegrating and Matrix-types of Fine Granules

Tadashi Yamamura; Masaaki Mori; Takashi Tan; Yasuo Izutsu; Yasuhiko Nakamura; Hirokazu Makita; Yu Imasato

Chemical & Pharmaceutical Bulletin | 1991

Particle Design of Enoxacin by Spherical Crystallizaion Technique. II. Characteristics of Agglomerated Crystals

Masumi Ueda; Yasuhiko Nakamura; Hirokazu Makita; Yu Imasato; Yoshiaki Kawashima

Chemical & Pharmaceutical Bulletin | 1986

Influence of Pharmaceutical Properties on Gastric Lesions Induced in Rats by AD-1590, a Non-steroidal Anti-inflammatory Drug

Terutaka Takahashi; Masaaki Mori; Yuko Uezono; Hirokazu Makita; Yutaka Nakanishi; Yu Imasato

Archive | 1990

Rasch freisetzendes orales teilchenfoermiges pharmazeutisches praeparat, dessen unangenehmer geschmack maskiert ist. Rapidly releasing oral pharmaceutical particulate of preparation, the unpleasant taste is masked.

Yoshimi Shirai; Kiyomi Sogo; Yasuhiko Nakamura; Hiroshi Fujioka; Hirokazu Makita

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Yasuhiko Nakamura

Meijo University

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Yu Imasato

Kyushu University

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Masaaki Mori

Yokohama City University Medical Center

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Terutaka Takahashi

Kyoto University

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Yutaka Nakanishi

Kyushu University

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Masumi Ueda

Gifu Pharmaceutical University

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Yoshiaki Kawashima

Gifu Pharmaceutical University

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Takashi Tan

Kyushu University

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