Hiroko Kawano
Kobe Gakuin University
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Featured researches published by Hiroko Kawano.
Development Growth & Differentiation | 1984
Tadanori Mayumi; Hiroko Kawano; Yuichi Kawai; Takao Hama
The effects of ergothioneine on spermatozoa and ova were investigated in vitro and in vivo. Spermatozoa were treated with ergothioneine in vitro, and injected into the uterine cavity of female mice immediately after the induction of superovulation. The ova were recovered 24 hr later and assessed for fertilization. Preincubation of spermatozoa with ergothioneine resulted in a significant increase in the fertilization rate. When ova were inseminated in the same manner in vitro with spermatozoa treated with 0.1 or 1.0 mM of ergothioneine, the penetration rate was significantly increased. These results suggest that ergothioneine is effective in inducing both capacitation and the acrosome reaction of mouse spermatozoa. Ergothioneine at concentrations of 0.1 and 1.0 mM in the preincubation medium was also effective in inducing the acrosome reaction of guinea pig spermatozoa. However, it had no significant effect on the development of 2‐cell ova in vitro.
Inflammation | 1987
Norio Itoh; Takashi Toyohama; Hiroshi Okamoto; Hiroko Kawano; Tadanori Mayumi; Takao Hama
Hepatic synthesis as well as plasma levels of T-kininogen, a protein precursor of T-kinin (Ile-Ser-bradykinin), increase in rats following the induction of acute inflammation. Studies have been undertaken to elucidate an involvement of inflammatory leukocytes in the acute-phase response of T-kininogen. Peritoneal exudate cells (PEC) were prepared from rats six days after the intraperitoneal injection of Freunds complete adjuvant. By transfer of these leukocytes into the peritoneal cavity of normal rats, plasma kininogen levels of these recipients increased about threefold after one day. Secretion of kininogen from rat hepatocytes in primary culture was enhanced about twofold by coculturing with PEC. A similar effect was also obtained by adding culture supernatant of these leukocytes into hepatocytes, and the increased levels of kininogen in culture medium of hepatocytes was due to the increased levels of T-kininogen. From these results, it was concluded that leukocytes in the inflammatory site, probably macrophages, release some substance(s) which stimulate(s) the hepatic synthesis of T-kininogen.
Chemosphere | 1985
Masami Fujii; Tadanori Mayumi; Yuichi Kawai; Machiko Namikawa; Hiroko Kawano; Takao Hama
BHA was administered to rats at doses of 5 or 500 mg/kg for seven days. 14C-BHA absorption was investigated on the eighth day and compared with animals receiving a single dose of 5 or 500 mg/kg BHA. Absorption of 14C-BHA was proportionately greater at the high dose rats. 14C distribution was 3–6 times higher in the forestomach than in the pyloric region of the stomach. The urinary excretion of BHA conjugates was not dependent on pretreatment with BHA or on the dose.
Chemical & Pharmaceutical Bulletin | 1982
Hiroko Kawano; Mieko Otani; Keiko Takeyama; Yuichi Kawai; Tadanori Mayumi; Takao Hama
Chemical & Pharmaceutical Bulletin | 1978
Tadanori Mayumi; Hiroko Kawano; Yoshiko Sakamoto; Etsuji Suehisa; Yuichi Kawai; Takao Hama
Chemical & Pharmaceutical Bulletin | 1983
Hiroko Kawano; Hiroomi Murata; Sadafumi Iriguchi; Tadanori Mayumi; Takao Hama
Journal of Nutritional Science and Vitaminology | 1977
Nanaya Tamaki; Masayuki Nakamura; Mitsuko Harada; Keiko Kimura; Hiroko Kawano; Takao Hama
Chemical & Pharmaceutical Bulletin | 1982
Hiroko Kawano; Fumiko Higuchi; Tadanori Mayumi; Takao Hama
Toxicology Letters | 2005
Kyong-Son Min; Naoko Tanaka; Taeko Horie; Hiroko Kawano; Noriko Tetsuchikawahara; Satomi Onosaka
Chemical & Pharmaceutical Bulletin | 1983
Hiroko Kawano; Kei Cho; Yasuyo Haruna; Yuichi Kawai; Tadanori Mayumi; Takao Hama