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Hiromi Ohtomo

Okayama University

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Heterocycles | 1990

Pollycyclic N-Hetero Compounds. XXXI. Synthesis and Anti-platelet Aggregation Activity of 4-Substituted 5,6-Dihydrobenzo[h]quinazolines

Takashi Hirota; Kenji Sasaki; Hiromi Ohtomo; Ayako Uehara; Taiji Nakayama

Title compound were synthesized by the reaction of 4-chloro-5,6-dihydrobenzo[h]-quinazoline with amines

Synthetic Communications | 2011

Polycyclic N-Heterocyclic Compounds, Part 68: Reactions of 3-(2-Bromoethyl)quinazolin-4(3H)-one and 3-(2-Bromoethyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one with Primary Alkylamines via a Dimroth-Type Rearrangement

Kensuke Okuda; Hiromi Ohtomo; Tsuyoshi Tagata; Takashi Hirota; Kenji Sasaki

Abstract The reaction of 3-(2-bromoethyl)quinazolin-4(3H)-one with ethyl- and n-propylamine gave abnormal fused 3-alkyl-4-alkyliminoquinazolines via a Dimroth-type rearrangement, as well as normal substituted 3-(2-alkylaminoethyl) derivatives in methanol. The reaction of 3-(2-bromoethyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one with primary alkylamines was also investigated for the scope of this rearrangement reaction.

Heterocycles | 1990

Polycyclic N-hetero compounds. XXXI. Synthesis and anti-platelet aggregation activity of 4-substituted 5,6-dihydrobenzo[h]quinazolines

Takashi Hirota; Kenji Sasaki; Hiromi Ohtomo; Ayako Uehara; Taiji Nakayama

Journal of Heterocyclic Chemistry | 1990

Polycyclic N-hetero compounds. XXXIII. Syntheses of 4-substituted 6,7-dihydro-5H-benzo[6,7]-cyclohepta[1,2-d]pyrimidines and their inhibitory activities on platelet aggregation and on reserpine-induced hypothermia

Kenji Sasaki; Takashi Hirota; Yuichi Arimoto; Yoshiko Satoh; Hiromi Ohtomo; Taiji Nakayama

Journal of Heterocyclic Chemistry | 1993

Polycyclic N-hetero compounds. XLIII. Syntheses and properties of 2-substituted 1-acetoxy-6-acetyl-5,6-dihydro-4H-imidazo[1′,2′:1,6]-pyrimido[5,4-d][1]benzazepines viaN-(6,7-dihydro-5H-pyrimido[5,4-d]-[1]benzazepin-4-yl)amino acids and their analogous mesoionic compounds, and their related compounds as a series of potential blood platelet aggregation inhibitors

Tomohisa Nagamatsu; Yoshiji Hantani; Kenji Sasaki; Hiromi Ohtomo; Taiji Nakayama; Takashi Hirota

Chemical & Pharmaceutical Bulletin | 2010

Polycyclic N-Heterocyclic Compounds. Part 62: Reaction of N-(Quinazolin-4-yl)amidine Derivatives with Hydroxylamine Hydrochloride and Anti-platelet Aggregation Activity of the Products

Kensuke Okuda; Ying Xue Zhang; Hiromi Ohtomo; Takashi Hirota; Kenji Sasaki

Journal of Heterocyclic Chemistry | 1993

Polycyclic N-heterocyclic compounds. XLV. Synthesis of 4-substituted 5,6- dihydrobenzo[h]quinazolines and 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2- d]pyrimidines and their inhibitory activity on platelet aggregation

Kenji Sasaki; Yuhki Sekiya; Hideko Fujiwara; Hiromi Ohtomo; Taiji Nakayama; Takashi Hirota

Journal of Heterocyclic Chemistry | 1991

Polycyclic N-hetero compounds. XXXV. Syntheses and anti-platelet aggregation activity of 5,6-Dihydro-4H-benzo[3,4]cyclohept[1,2-e]imidazo[1,2-c]pyrimidines with an oxygen function at the 1-position

Kenji Sasaki; Yuhki Sekiya; Tomohisa Nagamatsu; Hiromi Ohtomo; Taiji Nakayama; Takashi Hirota

Journal of Heterocyclic Chemistry | 1996

Polycyclic N-heterocyclic compounds. 51. Synthesis of novel 12-substituted 11,13,15-triazasteroidal compounds and their inhibitory activity on platelet aggregation

Kenji Sasaki; Takeshi Arichi; Hiromi Ohtomo; Taiji Nakayama; Takashi Hirota

Heterocycles | 1995

Polycyclic N-heterocyclic compounds. 47 Synthesis and evaluation of anti-platelet aggregation activity of 11,13,15-triazasteroid and related compounds

Kenji Sasaki; Tomohiro Funabashi; Hiromi Ohtomo; Taiji Nakayama; Takashi Hirota

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Kenji Sasaki

Okayama University

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Takashi Hirota

Okayama University

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Taiji Nakayama

Okayama University

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Kensuke Okuda

Gifu Pharmaceutical University

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Tomohisa Nagamatsu

Okayama University

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Yoshiji Hantani

Okayama University

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Ayako Uehara

Okayama University

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Tsuyoshi Tagata

Okayama University

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Ying Xue Zhang

Okayama University

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Yuhki Sekiya

Okayama University

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