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Hironobu Tamura

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Publication

Featured researches published by Hironobu Tamura.

Mutation Research-genetic Toxicology and Environmental Mutagenesis | 1999

Mutation induction by N-propyl-N-nitrosourea in eight Muta™Mouse organs

Takumi Hara; Koichi Hirano; Noriko Hirano; Hironobu Tamura; Hajime Sui; Tohru Shibuya; Atsushi Hyogo; Toshiko Hirashio; Hiroshi Tokai; Yasuhiro Yamashita; Kouhei Kura

As a part of the 2nd Collaborative Study for the Transgenic Mouse Mutation Assay, we studied the organ specificity and the temporal changes in mutant frequency (MF) of the lacZ gene following intraperitoneal injection of 250 mg/kg N-propyl-N-nitrosourea into male MutaMouse. We used a positive selection system and examined eight organs, i.e., bone marrow, liver, kidney, lung, spleen, brain, heart, and testis. The chemical caused a significant increase in MF in all organs except for brain, and the bone marrow was the most sensitive organ, exhibiting a MF on day 7 that was 10 times that of the control. The MF increased from day 7 to day 28 in liver, kidney, and testis, while it decreased in bone marrow. The relationship between the results of this study and the target organs of carcinogenesis, and the cause of the temporal changes in MF, are discussed.

Environmental and Molecular Mutagenesis | 2001

Evaluation of the rodent micronucleus assay by a 28‐day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)–Mammalian Mutagenicity Study Group (MMS)

Shuichi Hamada; Sizuyo Sutou; Takeshi Morita; Akihiro Wakata; Shougo Asanami; Satoko Hosoya; Shigenari Ozawa; Koji Kondo; Madoka Nakajima; Hiroyasu Shimada; Koichi Osawa; Yasushi Kondo; Norihide Asano; Sei-ichi Sato; Hironobu Tamura; Nobuhiro Yajima; Richard Marshall; Catherine Moore; David H. Blakey; Leonard M. Schechtman; James L. Weaver; Dorothea K. Torous; Ray Proudlock; Seiichi Ito; Chiaki Namiki; Makoto Hayashi

Journal of Toxicological Sciences | 1995

THE MECHANISM OF LACTITOL (NS-4) IN INDUCING ADRENOMEDULLARY PROLIFERATIVE LESION IN RATS

Masaru Yoshida; Seitaro Ishibashi; Motokuni Nakazawa; Hironobu Tamura; Hiroshi Uchimoto; Kazushiro Kawaguchi; Kenichi Yoshikawa; Yasuhisa Hamasu; Nobuyoshi Sumi

Journal of Toxicological Sciences | 1995

ORIGIN OF SERUM ALP ISOZYME AND IT CHANGE DURING THE FASTING IN BEAGLE DOGS.

Seitaro Ishibashi; Yasuhisa Hamasu; Masaru Yoshida; Motokuni Nakazawa; Takahiro Adachi; Kenichi Yoshikawa; Hironobu Tamura; Nobuyoshi Sumi

Journal of Toxicological Sciences | 1995

MUTAGENICITY STUDIES OF MONTIRELIN HYDRATE (NS-3)

Keiko Iwakura; Hironobu Tamura; Yasuhiro Yamashita; Eita Kitayama; Yasuhisa Hamasu; Hisamitsu Nagasawa; Masataka Watanabe; Nobuyoshi Sumi

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan | 2000

A conaborative study of the mutagenicity assay using gpt delta transgenic mouse

Hironobu Tamura; Atsushi Hyogo; Madoka Nakajima; Nobuhiro Yajima; Takehiko Nohmi

Journal of Toxicological Sciences | 1997

THE MECHANISM OF INCREASED THYROIDAL FUNCTION CAUSED BY (±)-4-DIETHYLAMINO-1, 1-DIMETHYLBUT-2-YN-1-YL 2-CYCLOHEXYL-2-HYDROXY2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRIDTE(NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE, ADMINISTRATION IN RATS

Seitaro Ishibashi; Motokuni Nakazawa; Takeharu Tawaratani; Masaru Yoshida; Hironobu Tamura; Takahiro Adachi; Kazushiro Kawaguchi; Keiko Iwakura; Nobuyoshi Sumi; Katumi Wakabayashi

Journal of Toxicological Sciences | 1997

[Mutagenicity studies of RCC-36, the active metabolite of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence].

Hironobu Tamura; Yasuhiro Yamashita; Eita Kitayama; Keiko Iwakura; Masataka Watanabe; Nobuyoshi Sumi

Journal of Toxicological Sciences | 1997

MUTAGENICITY STUDIES OF (±)-4-DIETHYLAMINO-1, 1, -DIMETHYLBUT-2-YN-1-YL 2-CYCLHOEXYL-2-HYDROXY-2-PHENYLACETATE MONOHYDROCHLORIDE MONOHYDRATE (NS-21), A NOVEL DRUG FOR URINARY FREQUENCY AND INCONTINENCE

Masanori Otsuka; Yoshitsugu Kajiwara; Syozo Ajimi; Hiroko Shimazaki; Tsukasa Kikuno; Syozo Ogura; Tsunehiko Inai; Keijiro Kakimoto; Hironobu Tamura; Masataka Watanabe; Nobuyoshi Sumi

Journal of Toxicological Sciences | 1996

MUTAGENICITY STUDIES OF PRULIFLOXACIN (NM441) AND THE ACTIVE METABOLITE (NM394)

Keiko Iwakura; Hironobu Tamura; Yasuhiro Yamashita; Masataka Watanabe; Nobuyoshi Sumi; Yasuhiro Shindo; Makoto Ando; Motoyoshi Kojima

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Nobuyoshi Sumi

Okayama University

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Yasuhiro Yamashita

Okayama University

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Madoka Nakajima

University of Shizuoka

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Hiroyasu Shimada

Nagoya City University

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Koichi Osawa

Taisho Pharmaceutical Co.

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Norihide Asano

Nitto Denko

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Noriko Hirano

Taisho Pharmaceutical Co.

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Sei-ichi Sato

Japan Tobacco

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Shuichi Hamada

Kyoto University

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Takehiko Nohmi

Tohoku University

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