Hiroo Sueyama
Niigata University
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Featured researches published by Hiroo Sueyama.
International Journal of Radiation Oncology Biology Physics | 1995
Kunio Sakai; Hideki Inakoshi; Hiroo Sueyama; Junichi Oda; Takeshi Ito; Emiko Tsuchida; Tadashi Sugita; Yasuo Matsumoto; Mari Saito; Akira Saito
PURPOSE The feasibility of a concurrent chemoradiotherapeutic protocol for patients with inoperable esophageal squamous cell carcinoma was tested. METHODS AND MATERIALS Concurrent chemoradiotherapy using protracted low-dose continuous infusions of five-fluorouracil (5-FU; 250-300 mg/m2/24 h) and standard external beam irradiation was given to 28 patients with inoperable esophageal squamous cell carcinoma between November 1991 and June 1993. RESULTS For 25 patients receiving a total dose of > or = 60 Gy and concurrent 5-FU infusion for more than 5 weeks, the complete response rate was 52%. Local progression-free rate in this chemoradiotherapy group was significantly higher than the historical controls treated by radiotherapy alone (p < 0.05). A multivariate analysis revealed the treatment scheme (concomitant chemoradiotherapy vs. radiotherapy alone) to be a significant factor in local control (p < 0.01). Swallowing pain (39%), anorexia (39%), and nausea (32%) were the most frequent early reactions. Serious late radiation complications have not been observed. CONCLUSION The concurrent chemoradiotherapy using protracted low-dose continuous infusion of 5-FU and standard radiotherapy is an effective and safe method to obtain a local control in inoperable esophageal squamous cell carcinoma.
Esophagus | 2005
Emiko Tsuchida; Kunio Sakai; Yasuo Matsumoto; Tadashi Sugita; Ryuta Sasamoto; Tadayoshi Yamanoi; Hiroo Sueyama; Takeshi Ito; Keisuke Sasai
BackgroundRadiotherapy plays an important role in salvaging patients who suffer locoregional recurrence; however, it displays poor prognosis. Because concurrent chemoradiotherapy offers superior treatment results compared to radiotherapy alone in patients with localized esophageal cancer, to improve survival rates, we treated patients displaying postoperative regional lymph node recurrence of esophageal squamous cell carcinoma using radiotherapy combined with protracted low-dose continuous infusion of 5-fluorouracil (5-FU).MethodsBetween January 1992 and December 2001, 14 patients with postoperative regional lymph node recurrence of esophageal squamous cell carcinoma were treated with concurrent chemoradiotherapy. Radiotherapy was delivered at 1.8–2.0 Gy/day, for a total dose of 56–70 Gy (median, 60 Gy). Chemotherapy was administered 5 days/week as continuous infusion of 5-FU (250–300 mg/m2) for at least 5 weeks. Median follow-up time was 27 months.ResultsTwelve patients demonstrated partial response, and 2 patients displayed stable disease. Response rate was therefore 86% (12/14). In-field recurrence occurred in 3 patients. Involved lymph nodes that recurred in the irradiation field were ≥40 mm in maximum diameter and invaded into the surrounding normal tissues. Local progression-free rate at 2 years was 72%. As an initial failure, 6 patients displayed out-field recurrence. Disease progression-free rate at 2 years was 42%. Overall survival rates at 1 and 2 years were 85% and 57%, respectively.ConclusionsConcurrent chemoradiotherapy using low-dose continuous infusion of 5-FU was effective for patients with postoperative regional lymph node recurrence of esophageal squamous cell carcinoma. Close follow-up is crucial, and further investigation is required to prevent out-field recurrence.
American Journal of Clinical Oncology | 1997
Hiroo Sueyama; Kunio Sakai; Tadashi Sugita; Takeshi Ito; Takayoshi Uemastu; Tadashi Nishimaki; Motoki Kaizu
A 60-year old male patient who had locally advanced esophageal carcinoma with bulky upper abdominal lymphadenopathy underwent neoadjuvant chemotherapy consisting of 5-fluorouracil (5-FU) and cisplatin (CDDP), followed by concurrent radiotherapy and chemotherapy using protracted low-dose continuous infusion of 5-FU and CDDP. The treatment brought about complete remission in the primary lesion and good partial remission in the upper abdominal lymphadenopathy. He subsequently underwent trans-hiatal esophagectomy after one cycle of adjuvant chemotherapy because local recurrence was suspected. Histopathologic study of the resected specimen demonstrated no malignant tissue in the primary lesion and the lymph nodes. The patient is still alive and disease-free at 26+ months. This result suggests that neoadjuvant chemotherapy followed by concomitant chemotherapy and radiotherapy for patients who have locally advanced squamous cell carcinoma of the esophagus with intensive abdominal lymphadenopathy may offer some chance for sterilization of local and regional metastases and longer survival.
The Journal of JASTRO | 2001
Kunio Sakai; Hiroo Sueyama; Mani Saito; Tadashi Sugita; Emiko Tsuchida; Yasuo Matsumoto; Ryuta Sasamoto; Takayoshi Uematsu; Junichi Oda; Takeshi Ito; Hideki Inakoshi
The Journal of JASTRO | 1995
Teppei Shimizu; Yoshiaki Tanaka; Yasumasa Nishimura; Masahiro Hiraoka; Susumu Wada; Hiromi Terashima; Hirofumi Tamura; Iwao Hashida; Sumio Suyama; Hideyuki Muramoto; Hiroo Sueyama
The Journal of JASTRO | 1997
Naofumi Hayabuchi; Yoshihiko Onizuka; Yuta Sibamoto; Hiroo Sueyama; Noboru Fukuhara; Hideo Niibe; Takashi Murata; Toshiyuki Nisida; Kazushi Kisi
J Jpn Soc Ther Radiol Oncol | 1997
Hideki Inakoshi; Kunio Sakai; Hiroo Sueyama; Yoshihiro Ogawa; Mitsuru Kobayashi; Hiroshi Wakushima; Toya Obara; Yuta Shibamoto
Japanese Journal of Hyperthermic Oncology | 1996
Hiromi Terashima; Hajime Imada; Satoru Uehara; Kazuo Hate; Susumu Wade; Yasushi Shimamure; Nobukazu Huwa; Hisato Nagano; Kenji Nagata; Masaaki Kataoke; Yoshihiro Ogawa; Hiroo Sueyama; Iwao Hashida; Tetsuya Yamada; Masahiro Hiraoka
The Journal of JASTRO | 1997
Iwao Tsukiyama; Masaya Furuta; Daisuke Takenaka; Michihide Mitsumori; Susumu Wada; Hiroo Sueyama; Sumio Suyama; Hiromi Terashima; Tetsuya Yamada; Masaaki Kataoka
Journal of Radiation Research | 1997
Kunio Sakai; Hiroo Sueyama; Tadashi Sugita; Emiko Tsuchida; Yasuo Matsumoto; Takayoshi Uematsu