Hiroshi Hikita
Kyoto Prefectural University of Medicine
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Featured researches published by Hiroshi Hikita.
International Journal of Gastrointestinal Cancer | 2005
Masashi Kanai; Ayao Torii; Akihiko Hamada; Yoko Endo; Yasuhiro Takeda; Masashi Yamakawa; Hiroshi Hikita; Haruhiro Nishikawa; Jiro Ochi; Masashi Noguchi; Ippei Kashu; Takaki Sakurai
We recently experienced an 87-yr-old man with gastric yolk sac tumor. Preoperative diagnosis was poorly differentiated adenocarcinoma in the cardia of stomach without apparent metastasis. A total gastrectomy was performed. The precise histological examination after surgery revealed the tumor was composed of pure gastric yolk sac tumor without adenocarcinomatous components. The surgical margin and the resected lymph nodes were histologically negative for the tumor and a curative resection was performed. Five months after the operation, enlargement of the intraabdominal lymph nodes occurred with elevation of serum alpha fetoprotein (AFP), and the patient died 2 mo later. Gastric yolk sac tumors are very rare, and only six cases of gastric yolk sac tumors have been previously reported in the literature. Five out of six cases are accompanied by components of adenocarcinoma, and our present case is the second report of pure gastric yolk sac tumor to the best of our knowledge.
Journal of Gastroenterology | 1995
Tomoki Nakajima; Takeshi Deguchi; Keizo Kagawa; Hiroshi Hikita; Kazushige Ueda; Tatsuo Katagishi; Tohru Ohkawara; Masamichi Kakusui; Hiroyuki Kimura; Takeshi Okanoue; Kei Kashima; Tsukasa Ashihara
Apoptosis plays a major role in the regression of mitogen (lead nitrate)-induced hepatic hyperplasia. We compared the in situ end-labeling (ISEL) technique with the conventional detection of apoptotic bodies in this process. In hematoxylin and eosin (H&E) sections, apoptosis is usually recognizable by the presence of apoptotic bodies (apoptosis phase 2). Although the early phase of apoptosis (apoptosis phase 1) can be detected as a prekaryorrhectic appearance in H&E sections, it is difficult to detect and is easily overlooked. On the other hand, ISEL presents intense staining mainly in phase 1 and weak or negative staining in phase 2. Thus, simultaneous investigation by these two methods in two serial sections is the most reliable way to calculate the incidence of apoptosis and gives us precise information on the stages of apoptosis in situ. Since the colorized signals of ISEL are much easier to detect than apoptotic bodies in H&E sections, ISEL is particularly useful for liver tissues, where the incidence of apoptosis is low.
Digestive Endoscopy | 2003
Takehiko Tsumura; Ayao Torii; Shinya Fujita; Jun Takeda; Hiroshi Hikita; Haruhiro Nishikawa; Jiro Ochi
Recently, the usefulness of the oblique transparent cylinder (OTC) in colonoscopy has been reported. In this study, the efficacy of two newly designed OTCs was evaluated. Colonoscopy performed by six experienced endoscopists in 1005 cases and by one inexperienced endoscopist in 177 cases was analyzed. Short (S) and ultra short (US) cylinders, shorter in length than a conventional long (L) cylinder, were used. The use of OTCs in colonoscopy contributed to a significantly faster insertion into the cecum. The average time to reach the cecum for experienced endoscopists were 12.4 ± 0.3 min without a cylinder, 9.0 ± 0.3 min with a US cylinder, 8.5 ± 0.4 min with an S cylinder and 6.9 ± 0.8 min with an L cylinder, respectively. The visual field and handling of the endoscope were more improved with the S cylinder than the conventional L cylinder. On the other hand, with the L cylinder, the success rate of one inexperienced endoscopist for total colonoscopy reached more than 90% and mean insertion time to reach the cecum was 16.4 ± 1.8 min 7‐months later. Both the success rate and average insertion time for the inexperienced endoscopist were satisfactory considering the rather short learning period. The OTCs were effective in reducing the insertion time. The use of the S cylinder overcame some of the disadvantages of the L cylinder; however, the L cylinder was helpful in improving the technique of an inexperienced endoscopist.
Journal of Medical Ultrasonics | 2003
Yoko Endo; Hiroshi Hikita; Akihiko Hamada; Keisuke Oe; Ayao Torii; Haruhiro Nishikawa; Jiro Ochi; Yumiko Mori; Yumiko Aoki; Takaki Sakurai
A 22-year-old woman was admitted to this institution because of severe liver dysfunction that looked like acute hepatitis. Abdominal ultrasonography revealed a liver mass 20 mm in diameter that resembled the bull’s-eye sign. Enhanced CT revealed a low-density mass. The mass was hypointense in T1-weighted MRI images and slightly hyperintense in T2-weighted MRI images. Needle biopsy of the liver under ultrasound guidance led to a diagnosis of solitary necrotic nodule of the liver. The tumor consisted of coagulation necrosis surrounded by fibrotic tissue. These pathologic features were consistent with the Imaging findings.
International Hepatology Communications | 1993
Hisashi Tada; Keizo Kagawa; Hiroshi Hikita; Takayuki Takeuchi; Takeshi Okanoue; Kei Kashima; Yoji Urata; Tsukasa Ashihara
Abstract To analyze EGF binding activity in liver regeneration at cell cycle level, we performed the double measurement of nuclear DNA content and cellular bound EGF content in freshly isolated rat hepatocytes from normal and regenerating liver after 67% hepatectomy using autostaging cytofluorometry. The data demonstrated that the bound EGF content of resting cells increased in proportion to their DNA content, while cycling cells had significantly consistently lower bound hEGF throughout cell cycle. These changes are supposed to reflect ‘down-regulation’ of EGF receptor at the cell cycle level, and the data suggested a major role of endogenous EGF in cell proliferation during liver regeneration.
Digestive Endoscopy | 1991
Masafumi Matsumoto; Keizo Kagawa; Hiroyuki Shintani; Akitsugu Nishiyama; Masayuki Mizuno; Kazuo Sakabe; Hiroshi Hikita; Takayuki Takeuchi; Hisashi Tada; Susumu Fukui; Takeshi Deguchi; Takeshi Okanoue; Kei Kashima
Abstract: Histopathologically, early lesions of primary biliary cirrhosis (PBC) are focal within the liver and there is segmental involvement of the bile ducts. In addition, the development of PBC is variable within the liver. PBC is characterized by the following laparoscopic findings: reddish patch, mesh‐like white marking and gentle undulation, etc.
Kanzo | 1993
Hiroyuki Kimura; Keizo Kagawa; Masamichi Kakusui; Tohru Ohkawara; Tomoki Nakajima; Kazuo Sakabe; Masafumi Matsumoto; Masayuki Mizuno; Kazushige Ueda; Hiroshi Hikita; Takeshi Deguchi; Takeshi Okanoue; Kei Kashima
Acta Histochemica Et Cytochemica | 1994
Tomoki Nakajima; Keizo Kagawa; Takeshi Deguchi; Hiroshi Hikita; Takeshi Okanoue; Kei Kashima; Eiichi Konishi; Tsukasa Ashihara
Kanzo | 1990
Hiroshi Hikita; Keizo Kagawa; Takayuki Takeuchi; Hisashi Tada; Masafumi Matsumoto; Masayuki Mizuno; Kazuo Sakabe; Takeshi Deguchi; Takeshi Okanoue; Kei Kashima
Kanzo | 1990
Yoshiharu Ohta; Takeshi Okanoue; Masaharu Ohta; Michio Morimoto; Yoshito Ito; Hiroshi Hikita; Keizo Kagawa