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Dive into the research topics where Hiroshi Kakizaki is active.

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Featured researches published by Hiroshi Kakizaki.


Diseases of The Colon & Rectum | 1993

Therapeutic experience of hyperbaric oxygenation in radiation colitis

Teruhiro Nakada; Yoko Kubota; Isoji Sasagawa; Hitoshi Suzuki; Toshiyuki Yamaguchi; Manabu Ishigooka; Hiroshi Kakizaki

PURPOSE: The usefulness of the hyperbaric oxygenation in a patient with radiation colitis was evaluated. METHODS: The patient had severe bleeding from the large bowel which resulted from a pelvic radiation therapy for prostatic carcinoma and was histologically diagnosed as radiation colitis. Hyperbaric oxygenation therapy consisting of 100 percent oxygen inhalation at two absolute atmospheric pressures 90 minutes daily for 30 days was performed. RESULTS: The treatment succeeded in stopping gross hemorrhage and reversed endoscopic bowel findings. CONCLUSION: The effect of the hyperbaric oxygenation therapy of radiation colitis is elucidated.


Cancer Chemotherapy and Pharmacology | 1996

Electropermeabilization in bladder cancer chemotherapy.

Yoko Kubota; Teruhiro Nakada; Hiroshi Yanai; Hiroshi Kakizaki; Isoji Sasagawa; Morihiro Watanabe

Abstract Purpose: Electropermeabilization has been used for the introduction of genes into cells. Using this technique, we introduced the cytotoxic drug bleomycin (BLM) into cells and examined whether the technique might be useful for the treatment of bladder cancer. Materials and methods: For electropermeabilization in vitro, we used YTS-1 cells, a human transitional cell carcinoma line. Aliquots of cell suspension were mixed with a solution of BLM and immediately exposed to electric pulses. A high-power pulse generator was used to supply square-shaped pulses of 1250 V/cm (100 μs, eight pulses). After a 2-h post-shock incubation, cells were washed and incubated for one further hour. Then the concentration of BLM in the cells was measured using a bioassay. For electropermeabilization of tissue, we used normal male Wistar rats. The bladder was exposed and 10 mg/kg BLM was injected into the caudal vein. A series of eight pulses with a time constant of 100 μs at an electric field intensity of 1000 V/cm was applied. The bladder, liver and lungs were extracted 1 h later and prepared for quantification of the BLM concentration using the bioassay. Results: Electrotreated cells contained significantly higher concentrations of BLM than nonelectrotreated cells. The concentration of BLM 1 h after electrotreatment in bladder tissue was 2.7 times higher than that in nonelectrotreated bladder tissue. Conclusion: The electropermeabilization technique has the potential to serve as a new and effective modality for the treatment of bladder cancer.


The Journal of Urology | 1999

Testicular teratoma in a man with XX/XXY mosaic Klinefelter's syndrome

Shingo Matsuki; Isoji Sasagawa; Hiroshi Kakizaki; Yasuhiro Suzuki; Teruhiro Nakada

Patients with Klinefelter’s syndrome have an increased incidence of mediastinal germ cell tumors1 but testicular tumors are rare.* We describe testicular teratoma in a man with the xx/xxy mosaic Klinefelter syndrome. To our knowledge our case represents the first report of )(x/xxy mosaic Klinefelter’s syndrome associated with testicular teratoma. CASE REPORT A 62-year-old man was referred to our hospital for painless enlargement in the right scrotum. Medical and familial histories were unremarkable. He was well developed, weighing 61 kg., and was 170 cm. tall. A female type distribution of pubic hair was noted. Neither malformations nor gynecomastia was seen. The right testis was enlarged (about 30 ml. in volume) and firm but not tender. Scrota1 skin, epididymides, spermatic cord and inguinal region were normal. The left testis was atrophic and about 1 ml. in volume. Laboratory investigations, including hemogram, blood chemistry studies and urine cytology, were within normal limits. Plasma levels of P-subunit human chorionic gonadotropin, a-fetoprotein and carcinoembryonic antigen were also within normal ranges. Plasma luteinizing hormone, folliclestimulating hormone and testosterone were 27 mIU/ml. (normal 1.8 to 5.2), 69 mIU/ml. (normal 2.9 to 8.2) and 48 ng./dl. (normal 250 to 1,000), respectively. Chromosomal analysis revealed a 46,XX/47,XXY pattern, diagnostic of Klinefelter’s mosaicism (fig. 1). Abdominal computerized tomography did not show enlargement of para-aortic lymph nodes. At high orchiectomy the right testis appeared yellow-white and well circumscribed, approximately 55 X 40 X 40 mm. When the testis was incised hair was noted (fig. 2). Histologically the tumor was classified as a mature teratoma with multiple well differentiated tissue. The patient is alive and apparently tumor-free 10 months postoperatively. DISCUSSION


International Journal of Urology | 1994

MALIGNANT LYMPHOMA IN THE FEMALE URETHRA

Hiroshi Kakizaki; Teruhiro Nakada; Osamu Sugano; Hiroaki Kato; Mitsunori Yamakawa

Primary malignant lymphomas in the female urethra are extremely rare. We report a 63‐year‐old woman who presented with a localized tumor of the urethral meatus. The tumor was classified as a non‐Hodgkins malignant lymphoma, a diffuse, small cleaved cell type according to the Working Formulation classification. Immunohistochemistry confirmed that the tumor was derived from B cells. The patient underwent chemotherapy and remains free from evidence of the disease 3yr after excision. To our knowledge she is the seventh case of malignant lymphoma in the female urethra reported in the English literature.


The Journal of Urology | 1998

A BOY WITH INTRACHROMOSOMAL TRIPLICATION OF THE X CHROMOSOME

Shingo Matsuki; Isoji Sasagawa; Hiroshi Kakizaki; Keiichi Itoh; Teruhiro Nakada

A structurally abnormal X chromosome is often present in female individuals with some or all features of Turner’s syndrome. In most cases there is accompanying mosaicism for a 45,X or normal cell line.’ However, a structural abnormality of the X chromosome is rare in male subjects. We describe a boy with intrachromosomal triplication of the X chromosome. To our knowledge our case represents the first report of X chromosome triplication without mosaicism. CASE REPORT


The Journal of Urology | 1994

High level of noncollagenous protein of spermatic vein in patients with varicocele.

Teruhiro Nakada; Isoji Sasagawa; Yoko Kubota; Hitoshi Suzuki; Hiroshi Kakizaki; Yuichi Adachi

Spermatic vein specimens were removed from 46 patients with varicocele who underwent high ligation of the left spermatic vein and 11 men with renal cancer who underwent radical nephrectomy. Semen analysis was performed preoperatively and after 3 months, and the contents of noncollagenous protein, collagen and elastin in the spermatic vein were determined. The noncollagenous protein contents in the spermatic vein were greater in patients with grades 2 and 3 varicocele than in those with renal cancer (p < 0.001) and grade 1 varicocele (p < 0.01), respectively. Similar results, to a lesser extent, were also obtained for the contents of collagen. The content of elastin in each group was identical. Noncollagenous protein content correlated inversely with sperm count and sperm motility in all varicocele groups, as did collagen content in patients with grades 2 and 3 varicocele. These results indicate that there is an association between a large amount of noncollagenous protein and collagen in the spermatic vein and deterioration of the spermiogram in patients with grades 2 and 3 varicocele.


Urological Research | 2017

Prognostic utility of seasonal changes for diagnosis of ureteral stones

Hiroki Fukuhara; Osamu Ichiyanagi; Hiroshi Kakizaki; Norihiko Tsuchiya

Table 1 shows the results of the multivariate analysis with seven and eight (seven independent variables + seasonal factor) independent variables. All factors were associated with the presence of ureteral stones in the univariate analysis. The baseline and extended models were created with multiple logistic regression using each intercept and coefficient (Table 1). The optimal cut-off value of the ROC curves indicating the diagnostic performance of the baseline and extended models was 0.703. The AUC was 0.9667 [95% confidence interval (CI), 0.9448–0.9878] for the baseline model and 0.9737 (95% CI, 0.9553–0.9921) for the extended model. The sensitivity, specificity, PPV and NPV of the baseline model were 0.913, 0.962, 0.985, and 0.805, respectively, and those of the extended model were 0.983, 0.955, 0.983, and 0.955, respectively. Although both models were excellent for prediction of ureteral stones, the AUC for the extended model was significantly higher than that for the baseline model (p = 0.0057). Notably, the sensitivity improved from 0.913 to 0.983 and the NPV improved from 0.805 to 0.955 in the extended model after addition of the seasonal factor to the baseline model. The diagnostic performance between the baseline and extended models was compared with an arbitrary cut-off value of 0.703 using the continuous NRI and IDI methods. By incorporating the seasonal factor into the baseline model, 25 of 31 patients diagnosed with ureteral stones and classified as <0.703 were reclassified to a better category (≥0.703), and only one of 128 patients diagnosed with alternative disease and classified as <0.703 was reclassified incorrectly (≥0.703). This result suggests that the seasonal factor more effectively reclassified the patients with the ureteral stones without moving the patients with alternative diseases. The continuous NRI was 0.209 (95% CI, 0.074–0.343; p = 0.0023), and the IDI was 0.053 (95% CI, 0.035–0.072; p < 0.001), demonstrating that the extended Dear Editor,


International Urology and Nephrology | 1994

Changes of Urinary Kallikrein Excretion and Plasma Natriuretic Factor in a Patient with Primary Aldosteronism with Special Reference to Adrenal Histology

S. Hayami; T. Nakada; Hiroshi Kakizaki; T. Yagisawa; H. Kaneko; Y. Iijima; H. Obata; M. Miura

High level of urinary kallikrein excretion was observed in a 23-year-old man with primary aldosteronism. Unilateral adrenalectomy improved the clinical symptoms and normalized the urinary concentration of this vasoactive substance.Although plasma atrial natriuretic factor was not elevated, adrenal surgery lowered its concentration. Coexistence of an adrenal adenoma and lesions of nodular hyperplasia were detected in the removed adrenal gland.We summarize the clinical data of this patient and review the literature.


International Urology and Nephrology | 1991

Histological analysis of high-grade superficial bladder tumour

Yoko Kubota; Kazuo Numasawa; Hitoshi Suzuki; Hiroshi Kakizaki; Nobuhisa Ishii; Shunzo Kawamura; Teruhiro Nakada; Kazuhiro Suzuki

Segmental cystectomy or total cystectomy was performed in 26 patients with newly diagnosed stage T1, grade 3 transitional cell carcinoma of the bladder. Their histological specimens were assessed with regard to types of tumour cell spread, small vessel involvement and coexistent carcinoma in situ. Patients were followed for 12 to 141 months.Broad front type and tentacular type spread were seen in 57.7% and 38.5%, respectively. Small vessel involvement was seen in 38.5% of patients. Coexistent carcinoma in situ was found in as many as 65.4%. Urethral recurrence was found in 4 patients out of 26.These data suggest that the high incidence of coexistent carcinoma in situ may be the most important cause of the unsatisfactory prognosis for stage T1, grade 3 bladder cancer.


Urology case reports | 2017

Successful Treatment with Paclitaxel, Carboplatin, and Gemcitabine as Second-line Chemotherapy for Recurrent Urothelial Carcinoma of the Bladder with Glandular Differentiation After Radical Cystectomy: A Case Report

Hiroki Fukuhara; Hiroshi Kakizaki; Hisashi Kaneko; Takuya Yamanobe; Masaki Ushijima; Yuya Kuboki; Norihiko Tsuchiya

Urothelial carcinoma of the bladder (UCB) with glandular differentiation is a histological variant (HV) that is more likely to have positive extravesical tumors or nodes than those in pure UCB. Cisplatin-based neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) is more effective for pure UCB; however, few reports are available on second-line chemotherapy for recurrence of UCB with HV. Here we report a 65-year-old Japanese male diagnosed with local recurrence UCB with HV after NAC + RC who safely achieved complete response with paclitaxel, carboplatin, and gemcitabine combination chemotherapy.

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