Hiroshi Koganemaru

Urosepsis caused by Edwardsiella tarda

Edwardsiella tarda is a rare causative agent of human infection, predominantly associated with gastroenteritis. We describe a fatal case of urosepsis caused by E. tarda. The patient’s underlying condition of advanced uterine cancer may have contributed to the development of the infection.

Bacteremia caused by VanC-type enterococci in a university hospital in Japan: a 6-year survey

We retrospectively examined the clinical and microbiological characteristics of bacteremia caused by intrinsically vancomycin-resistant (VanC-type) enterococci in a university hospital in Japan. Five cases of Enterococcus gallinarum and four of Enterococcus casseliflavus bacteremia were identified during the 6 years of the survey. Of the nine cases, five were related to neutropenic states with hematologic diseases and four were related to biliary tract infection with hepatobiliary or pancreatic diseases. VanC-type enterococci were associated with 12% of all the enterococcal bacteremias, indicating that these species cause bacteremia more frequently in Japan than in previously reported areas.

Human Immunodeficiency Virus–Associated Burkitt's Lymphoma in Oral Cavity of Japanese Patient

olescents and is associated with EBV infection in 95% of cases. The jawbone is the most commonly affected region. The human immunodeficiency virus (HIV)related form develops in adults and is associated with positive titers of EBV in about 30% of cases. Abdominal extranodal lesions and lymph node involvement are common in this form of BL. 2,3 The oral manifestation of BL in HIV-infected individuals is, however, uncommon in the English-language medical literature, and its treatment and clinical course have not been fully documented. The present case report describes a patient with HIV-associated BL in the mandibular gingiva. This patient was successfully treated with intensive chemotherapy combined with highly active antiretroviral therapy (HAART). The characteristics of HIV-related oral BL are also discussed in the context of published reports. We report a case of BL arising in the oral cavity of a 45-year-old Japanese woman with HIV infection.

A case of bacteremia caused by Hafnia paralvei

The genus Hafnia, a member of the Enterobacteriaceae, is widespread in nature and rarely causes human infection. We describe a case of an 85-year-old Japanese man hospitalized consequent to suspected cholecystitis, in which Hafnia sp. was recovered from the blood culture concomitantly with Enterococcus faecalis. Sequencing of the 16S ribosomal RNA gene sequence and phenotyping with ID 32 E revealed that the recovered Hafnia sp. was considered to be Hafnia alvei genomosp. 2 (ATCC 29927), recently reclassified as Hafnia paralvei. The patient recovered uneventfully with antimicrobial therapies.

A case of secondary syphilis demonstrating nephrotic syndrome and a solitary intrahepatic mass in a human immunodeficiency virus-1-infected patient

A 37-year-old, human immunodeficiency virus-1-infected Japanese man was referred because of nephrotic syndrome following emergence of generalized skin rash. Serological tests for syphilis turned out to be positive within ten months of the referral. Abdominal echography incidentally revealed a solitary intrahepatic mass without a detectable blood flow in segment 7. The patients signs and symptoms, as well as the intrahepatic mass, resolved promptly after administration of amoxicillin. We consider that, in the present case, secondary syphilis caused the nephrotic syndrome and the intrahepatic mass, both of which have rarely been reported to date.