Hiroshi Kuwajima

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group.

Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.

A secoiridoid glucoside from Olea europaea

Abstract Besides two known glucosides, olcuropein and ligstroside, a new secoiridoid glucoside, oleuroside was isolated from Olea europaea and its structure

A quinol glucoside from Abeliophyllum distichum

Abstract Besides the known glucosides, calceolarioside D, verbascoside, cornoside, rutin and a cyclohexanone derivative, halleridone, a new quinol glucoside, ne

A secoiridoid glucoside from Ligustrum japonicum

Abstract Besides several secoiridoid glucosides including 8-epikingiside, a new secoiridoid glucoside, methyl glucooleoside, was isolated from the ripe berries of Ligustrum japonicum and its structure elucidated.

Four secoiridoid glucosides from Fraxinus insularis

Abstract Investigation of the leaves of Fraxinus insularis has led to the isolation of four new secoiridoid glucosides, insularoside-3′- O - β - d -glucoside, insularoside-3′, 6‴-di- O - β - d -glucoside, insuloside and desrhamnosyloleoacteoside, together with ligstroside. The structures of the new compounds were determined on the basis of spectroscopic methods.

A secoiridoid glucoside from Fraxinus insularis

Abstract A new secoiridoid glucoside, insularoside, was isolated from Fraxinus insularis . The structural elucidation of insularoside by spectroscopic and chemical studies is described. The biogenesis of this glucoside is also briefly discussed.