Hiroshi Matsuno
Graduate School USA
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Featured researches published by Hiroshi Matsuno.
IEICE Transactions on Fundamentals of Electronics, Communications and Computer Sciences | 2006
Hiroshi Matsuno; Chen Li; Satoru Miyano
Petri nets have recently become widely accepted as a description method for biological pathways by researchers in computer science as well as those in biology. This paper gives an overview of Petri net formalisms to describe biological pathways and discusses their use in modelings and simulations for the systematic understandings of biological pathways. After reviewing the use of various types of Petri nets for the biological pathway modelings, we showed the examples that analyze fundamental properties of biological pathways using T-invariant, P-invariant, siphon, and trap. Applications of hybrid Petri nets for producing new biological hypotheses through simulations are also illustrated.
Archive | 2011
Natsumi Mitou; Hiroshi Matsuno; Satoru Miyano; Shin-Ichi T. Inouye
Mammalian circadian clock is composed of two feedback loops, a Per-Cry and Clock-Bmal loops. The role of Rev-Erb gene, which interconnects these two feedback loops by the inhibition of Bmal from PER/CRY complex, has been investigated through biological experiments as well as computational simulations. However, for the role of Ror gene, which exerts contrary effect on the same target gene Bmal as the Rev-Erb, enough consideration has not been paid so far. This paper first improves the previous hybrid functional Petri net (HFPN) model of the circadian clock so that both of the Per-Cry and Clock-Bmal loops can participate in the maintenance of the circadian oscillations. This improvement is incomplete, however, because a fixed level of PER/CRY eliminates all the circadian oscillations. Although this problem can be resolved by the introduction of Ror into the HFPN model, another inconsistency remains, Bmal oscillation is not abolished by the knock-out of the Cry. Then we further incorporate a hypothetical path into the HFPN model, succeeding in eliminating this inconsistency while keeping complementary actions of two feedback loop.
ITC-CSCC :International Technical Conference on Circuits Systems, Computers and Communications | 2008
Ren Wu; Hideyuki Inui; Manabu Sugii; Hiroshi Matsuno
Archive | 2004
Satoru Miyano; Hiroshi Matsuno
ITC-CSCC :International Technical Conference on Circuits Systems, Computers and Communications | 2015
Manabu Sugii; Hiroshi Matsuno
Archive | 2013
Manabu Sugii; Edgar Wingender; Hiroshi Matsuno
3d International ICST Conference on Bio-Inspired Models of Network, Information, and Computing Systems | 2010
Kanji Hioka; Yoshimasa Miwa; Chen Li; Qi-Wei Ge; Hiroshi Matsuno; Satoru Miyano
ITC-CSCC :International Technical Conference on Circuits Systems, Computers and Communications | 2008
Sayaka Kado; Ryo Okada; Manabu Sugii; Hiroshi Matsuno; Satoru Miyano
ITC-CSCC :International Technical Conference on Circuits Systems, Computers and Communications | 2008
Yoshimasa Miwa; Kanji Hioka; Chen Li; Hiroshi Matsuno; Satoru Miyano
The Proceedings of Conference of Chugoku-Shikoku Branch | 2004
Tomokazu Kono; Hironori Kitakaze; Masao Nagasaki; Atsushi Doi; Hiroshi Matsuno; Satoru Miyano