Hiroshi Noda

Experimental infection of mink with influenza A viruses

SummaryMink were found to be susceptible to the intranasal inoculation of human, swine, equine and avian influenza A viruses. The viruses were recovered until the 7th post inoculation (p.i.) day from the respiratory tract. The inoculated mink showed antibody response against these viruses. Contact infection in mink with A/Kumamoto/22/77 (H3N2) was possible.

Contact infection of mink with influenza A viruses of avian and mammalian origin

SummaryAvian influenza A virus Hav 7 N 2 was transmitted to mink by contact. Other avian influenza A viruses, Hav 4 Nav 1 and Hav 6 Nav 5, were not transmitted, and human, swine and equine influenza A viruses were transmitted to mink by a similar contact.

Human influenza virus infection in mink: Serological evidence of infection in summer and autumn

During the period from July to November 1981, 42 out of 128 young mink of a flock were found to possess antibodies against the viruses A/Bangkok/1/79 (H3N2) and A/Kumamoto/37/79 (H1N1), which were currently prevailing human influenza viruses. Seroconversion against A/Bangkok/1/79 was found in 12 mink from August to November. HI antibody titers of greater than 1: 128 were found in 8 out of 42 mink at the first examination in July and August. These findings suggest that infection with these human influenza viruses was present in this flock during the period from birth (the beginning of May) to autumn, the non-prevalent season in man. Attempts at virus isolation were unsuccessful.

Comparison of the effects of a multi-component vaccine and a formalin-killed cell vaccine on protection against enzootic of hemorrhagic pneumonia due to Pseudomonas aeruginosa in mink.

Effectiveness of a multi-component vaccine consisting of the common antigen (OEP) derived from Pseudomonas aeruginosa strain N 10 (serotype E) and toxoids of protease and elastase was compared with that of formalin-killed cells of strain N 10 on protection against enzootic of hemorrhagic pneumonia due to P. aeruginosa in mink. One administration of the multi-component vaccine (100 microgram each of OEP, protease toxoid and elastase toxoid) clearly prevented enzootic of hemorrhagic pneumonia due to P. aeruginosa (serotype G) in mink, while a vaccination of formalin-killed cells was much less effective in preventing an epidemic. The difference in mortality rates between two vaccines was remarkable.