Hiroshi Tanida

Stereoselective synthesis of erythro-3-fluorophenylalanine

Abstract Reductive amination of 3-fluorophenylpyruvic acid was found to give erythro-3-fluorophenylalanine with high selectivity.

Intramolecular OH π hydrogen bonding in 6- and 7-hydroxy-5,6,7,8-tetrahydro-5,8-methanoisoquinolines and their N-oxides

I.r. spectral measurements gave the frequency shift and integrated intensity of the hydroxy stretching band for the title compounds in dilute solutions of carbon tetrachloride and chloroform. Intramolecular OH π hydrogen bondings with characteristic differences were found.

FTIR and 1H NMR Spectral Study of 3-(Substituted Benzamido)-5,6,7,8-Tetrahydro-5,8-methanoiso-quinolines And Related Compounds

Abstract The title benzamide derivatives were synthesized. FTIR spectra of the benzamides having substituents p-NH2, p-OCH3, p-CH3 3, p-F, H 5,p-CI, p-CF3, p-CN, p-NO2 9 and m-Cl 10 and their related compounds were measured in dilute n-heptane, CCl4, CHCl3 and CH2Cl2 solutions. 1H NMR spectra of the benzamides were also measured in CDCl3 solution. Substituent effects on these spectra were investigated. The results were theoretically considered together with CNDO/2 calculation ones. Conformational analysis of 5 was carried out by the AMl method, and the results were compared with the X-ray structural data of 3, 5, 9 and 10. The intermolecular hydrogen bondings in crystals of the benzamides were examined based on the frequency shifts of their C=0 stretching vibration bands.