Hiroyuki Hichiya | Researchain

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Featured researches published by Hiroyuki Hichiya.

Drug Metabolism and Disposition | 2005

Functional characterization of five novel CYP2C8 variants, G171s, R186x, R186g, K247R, and K383N, found in a Japanese population

Hiroyuki Hichiya; Toshiko Tanaka-Kagawa; Akiko Soyama; Hideto Jinno; Satoru Koyano; Noriko Katori; Erika Matsushima; Hiroshi Tokunaga; Hideo Kimura; Narihiro Minami; Masaaki Katoh; Kenji Sugai; Yu-ichi Goto; Tomohide Tamura; Noboru Yamamoto; Yuichiro Ohe; Hideo Kunitoh; Hiroshi Nokihara; Teruhiko Yoshida; Hironobu Minami; Nagahiro Saijo; Masanori Ando; Shogo Ozawa; Yoshiro Saito; Jun-ichi Sawada

Drug Metabolism and Pharmacokinetics | 2004

Seven Novel Single Nucleotide Polymorphisms in the Human SLC22A1 Gene Encoding Organic Cation Transporter 1 (OCT1)

Masaya Itoda; Yoshiro Saito; Keiko Maekawa; Hiroyuki Hichiya; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Shogo Ozawa; Jun-ichi Sawada

Chirality | 2005

Change in enantioselectivity in bufuralol 1″‐hydroxylation by the substitution of phenylalanine‐120 by alanine in cytochrome P450 2D6

Kazufumi Masuda; Keietsu Tamagake; Yukie Okuda; Fumihiro Torigoe; Daisuke Tsuzuki; Takashi Isobe; Hiroyuki Hichiya; Nobumitsu Hanioka; Shigeo Yamamoto; Shizuo Narimatsu

Chirality | 2003

Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s

Shizuo Narimatsu; Chie Takemi; Shino Kuramoto; Daisuke Tsuzuki; Hiroyuki Hichiya; Keietsu Tamagake; Shigeo Yamamoto

Biochemical Pharmacology | 2002

Complementary DNA cloning and characterization of cytochrome P450 2D29 from Japanese monkey liver.

Hiroyuki Hichiya; Chie Takemi; Daisuke Tsuzuki; Shigeo Yamamoto; Kazuo Asaoka; Satoshi Suzuki; Tetsuo Satoh; Sumio Shinoda; Hiroyuki Kataoka; Shizuo Narimatsu

Biochemical Pharmacology | 2006

Catalytic roles of CYP2D6.10 and CYP2D6.36 enzymes in mexiletine metabolism : in vitro functional analysis of recombinant proteins expressed in Saccharomyces cerevisiae

Nobumitsu Hanioka; Yoshihito Okumura; Yoshiro Saito; Hiroyuki Hichiya; Akiko Soyama; Keita Saito; Kazuyuki Ueno; Jun-ichi Sawada; Shizuo Narimatsu

Biochemical Pharmacology | 2004

Cloning and functional expression of a novel marmoset cytochrome P450 2D enzyme, CYP2D30: comparison with the known marmoset CYP2D19

Hiroyuki Hichiya; Shino Kuramoto; Shigeo Yamamoto; Sumio Shinoda; Nobumitsu Hanioka; Shizuo Narimatsu; Kazuo Asaoka; Atsuro Miyata; Shin-ichi Iwata; Masahiro Nomoto; Tetsuo Satoh; Kimio Kiryu; Nobuhiko Ueda; Shinsaku Naito; Geoffrey T. Tucker; S.Wynne Ellis

Chemico-Biological Interactions | 2005

Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver : comparison with marmoset cytochrome P450 1A2

Shizuo Narimatsu; Maiko Oda; Hiroyuki Hichiya; Takashi Isobe; Kazuo Asaoka; Nobumitsu Hanioka; Shigeru Yamano; Sumio Shinoda; Shigeo Yamamoto

Drug Metabolism and Pharmacokinetics | 2003

Alteration in Catalytic Properties of Human CYP2D6 Caused by Substitution of Glycine-42 with Arginine, Lysine and Glutamic Acid

Daisuke Tsuzuki; Hiroyuki Hichiya; Yukie Okuda; Shigeo Yamamoto; Keietsu Tamagake; Sumio Shinoda; Shizuo Narimatsu

Journal of Health Science | 2004

Changes in the Enzymatic Properties of CYP2D6 by the Substitution of Phenylalanine at Position 120 by Alanine

Kazufumi Masuda; Hiroki Hashimoto; Keietsu Tamagake; Yukie Okuda; Daisuke Tsuzuki; Takashi Isobe; Hiroyuki Hichiya; Nobumitsu Hanioka; Shigeo Yamamoto; Shizuo Narimatsu

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