Hiroyuki Matsueda | Researchain

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Bioorganic & Medicinal Chemistry Letters | 2003

Pyrazole-O-glucosides as novel Na+-glucose cotransporter (SGLT) inhibitors

Koji Ohsumi; Hiroyuki Matsueda; Toshihiro Hatanaka; Ryusuke Hirama; Takashi Umemura; Akiko Oonuki; Nozomu Ishida; Yoko Kageyama; Katsumi Maezono; Nobuo Kondo

O-glucuronides and O-glucosides of a series of pyrazoles analogues were synthesized and evaluated for their SGLT inhibitory activity in brush border membrane vehicles (BBMVs) of rat kidney. O-glucosides of certain pyrazole analogues inhibited the transport of [(14)C]-glucose in BBMVs, and induced glucosuria in Wistar rats by intravenous injection.

Archive | 2001

Novel pyrazole derivatives and diabetes remedies containing the same

Koji Ohsumi; Takashi Umemura; Hiroyuki Matsueda; Toshihiro Hatanaka; Akiko Onuki; Katsumi Maezono; Yoko Kageyama; Nobuo Kondo

Archive | 2003

Preventive/remedy for diabetes

Toshihiro Hatanaka; Ryusuke Hirama; Nozomu Ishida; Yoko Kageyama; Nobuo Kondo; Katsumi Maezono; Hiroyuki Matsueda; Koji Ohsumi

Bioorganic & Medicinal Chemistry Letters | 2006

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Takashi Yamamoto; Seiji Niwa; Seiji Ohno; Tomoyuki Onishi; Hiroyuki Matsueda; Hajime Koganei; Hisayuki Uneyama; Shinichi Fujita; Tomoko Takeda; Morikazu Kito; Yukitsugu Ono; Yuki Saitou; Akira Takahara; Seinosuke Iwata; Masataka Shoji

Archive | 2002