Hisae Kakoi

On the structure of the Diels-Alder adducts obtained from (E)-3-methoxycarbonylmethylene-2-oxoindoline with unsymmetrical butadiene derivatives

The Diels-Alder reaction of (E)-3-methoxycarbonylmethylene-2-oxoindoline with trans- and cis-1,3-pentadienes gave a single product, respectively, in high yield. The structural features of these adducts were elucidated by proton nmr analysis and chemical transformations

Total synthesis of (±)-surugatoxin☆

Abstract Total synthesis of surugatoxin 1 , isolated from the toxic Japanese ivory shell ( Babylonia japonica ), was achieved from 6-bromoisatin by a stepwise ring construction involving two key steps: the stereospecific cyclization ( 17 → 18 ) and hydration ( 33b → 1 ).

Total synthesis of neosurugatoxin

Abstract Total synthesis of neosurugatoxin 2 , having a strong affinity for nicotinic receptors, in described.

Total synthesis of (-+)-surugatoxin

Abstract Total synthesis of surugatoxin 1, isolated from the toxic Japanese ivory shell ( Babylonia japonica ), was achieved from 6-bromoisatin by stepwise ring construction involving two key steps: the stereospecific cyclization (9→10) and hydration (17→1).

Synthesis of (±)-prosurugatoxin and ring transformation of prosurugatoxin into surugatoxin

Abstract Synthetic identification of prosurugatoxin and data indicating a possible mechanism for the ring transformation of prosurugatoxin into surugatoxin are presented.

Synthesis of (±)-Prosurugatoxin and Ring Transformation of Prosurugatoxin into Surugatoxin

Synthetic identification of prosurugatoxin and a possible mechanism for the ring transformation of prosurugatoxin into surugatoxin are presented

Model experiments on surugatoxin synthesis. an approach in the construction of the pentacyclic ring system

Synthesis of the ethyl ester 2a of the debromo-aglycone of surugatoxin 1 has been achieved in 10 steps starting from readily available ethyl 2-(2-oxo-3-indolenyl)-3-oxo-4-phthalimidobutyrate 3.

A New Hexagonal Cyclic Enol Phosphate of 6-b-Hydroxypropionyllumazines from the Marine Swimming Polychaete, Odontosyllis undecimdonta

A new hexagonal cyclic enol phosphate of 6-β-hydroxypropionyllumazine and its 3-methyl and 1,3-dimethyl derivatives were isolated from Odontosyllis undecimdonta

New epoxidation with m-chloroperbenzoic acid at elevated temperatures

Methyl methacrylate, a cyclic olefin, and two alk-1-enes are efficiently converted into their corresponding epoxides by m-chloroperbenzoic acid at elevated temperatures in the presence of a small amount of a radical inhibitor, which prevents thermal decomposition of the peracid.

(S)-6-(1-Hydroxypropyl)lumazine derivatives from the marine polychaete, Odontosyllis undecimdonta

(S)-6-(1-Hydroxypropyl)-3-methyllumazine (1) and (S)-6-(1- hydroxypropyl)-1,3-dimethyllumazine (3) were isolated from the swimming polychaete, Odontosyllis undecimdonta