Hisao Iwagami
Ajinomoto
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Publication
Featured researches published by Hisao Iwagami.
Nucleosides, Nucleotides & Nucleic Acids | 1992
Hiroshi Shiragami; Yasuhiro Tanaka; Yumiko Uchida; Hisao Iwagami; Kunisuke Izawa; Toshihide Yukawa
Abstract Regioselective 2′-O-deacetylation of 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)adenine (1) is achieved by treatment of 1 with β-cyclodextrin (β-CyD) / aq. NaHCO3 or N2H4·H2O / EtOH. The 9-(5-O-Acetyl-3-bromo-3-deoxy-β-D-xylo-furanosyl)adenine (2) obtained is a common intermediate for the synthesis of 2′,3′-dideoxy-adenosine (ddA) (7) and 9-(2-fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-adenine (F-ddA) (9).
Nucleosides, Nucleotides & Nucleic Acids | 1996
Hiroshi Shiragami; Yusuke Amino; Yutaka Honda; Masayuki Arai; Yasuhiro Tanaka; Hisao Iwagami; Toshihide Yukawa; Kunisuke Izawa
Abstract Practical method to produce 2′,3′-dideoxypurinenucleosides from 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)purines (1) was developed. High ratio of 2′,3′-dideoxynucleoside to 3′-deoxyribonucleoside was obtained by selecting the reaction conditions (solvent, pH and/or base), or changing 2′-acyloxy leaving group. The reaction mechanism was studied by deuteration experiments of 1a and 1-(3,5-di-O-acety1-2-bromo-2-deoxy-β-D-ribofuranosyl)thymine (12). †Dedicated to Dr. Yoshihisa Mizuno on the occasion of his 75th birthday.
Heterocycles | 1990
Hisao Iwagami; Naohiko Yasuda
Cyclization of amino acid hydrazide afforded a new class of heteroatom activated β-lactams. These compounds are potent parent nuclei which possess significant biological activity
Bulletin of the Chemical Society of Japan | 1991
Hisao Iwagami; Masanobu Yatagai; Masakazu Nakazawa; Haruo Orita; Yutaka Honda; Takashi Ohnuki; Toshihide Yukawa
Archive | 1992
Yutaka Honda; Hiroshi Shiragami; Hisao Iwagami; Masayuki Arai
Bulletin of the Chemical Society of Japan | 1990
Hisao Iwagami; Masakazu Nakazawa; Masanobu Yatagai; Toyoto Hijiya; Yutaka Honda; Hirokazu Naora; Takashi Ohnuki; Toshihide Yukawa
The Journal of Antibiotics | 1983
Naohiko Yasuda; Hisao Iwagami; Eiji Nakanishi; Teruaki Nakamiya; Yukio Sasaki; Teizo Murata
Archive | 1990
Hiroshi Shiragami; Yasuhiro Tanaka; Hisao Iwagami
Archive | 1989
Yutaka Honda; Hiroshi Shiragami; Hisao Iwagami; Masayuki Arai
Chemical & Pharmaceutical Bulletin | 1991
Yusuke Amino; Hisao Iwagami