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The International Journal of Applied Radiation and Isotopes | 1979

Tissue distribution of radioiodinated Ricinus lectins

M.Carmen Miguel; Hisao Sone; Masaharu Kojima; Gunki Funatsu

Abstract Two Ricinus lectins, ricin D and castor bean hemagglutinin (CBH) were iodinated with different numbers of diiodotyrosine (DIT) per molecule and trace labeled with iodine-125. The distribution in rat tissues after intraperitoneal and intravenous injection was investigated as a function of the degree of iodination of the lectins. A high specific affinity to the pancreas was found after intraperitoneal injection. About 6% of the administered dose/gram was localized in the pancreas at 30 min after injection of 3 DIT, 125 I-CBH and the pancreas to liver ratio was 16:1 (% dose/g). In the case of ricin D, the uptake in the pancreas was about 3% dose/g, at 30 min after injection of 3.6 DIT, 125 I-ricin D and the pancreas to liver ratio was 12:1 (% dose/g). No uptake, except in the liver, was observed after intravenous injection.


Radioisotopes | 1979

On Renal Excretion of Sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I

Masaharu Kojima; Yasuko Tomizono; Hisao Sone; Minoru Maeda

Sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I(IMPC-131I) was synthesized by isotope exchange with Na 131I in the molten state to evaluate its potential usefulness as a renal function and/or imaging agent. Tissue distribution and clearance characteristics of IMPC-131I are described. Tissue distribution experiments in rats indicated a very high renal concentration of radioactivity following intravenous administration. At 5 min the kidney took up 27.8% of the injected dose (16.1% dose per gram) and the total activity in the kidney still accounted for 9.8% of the injected dose at 30 min, with only 1.2% localizing in the liver. The ratios for kidney-to-liver in the concentration of IMPC-131I were always higher than those of hippuran -131I throughout the period of the experiment. Within 24 hr, 78.6% of the injected dose were excreted in the urine. The autoradiographic and the scannographic studies were also performed. The present results suggest that IMPC-131I has potential as a new agent for both funciton and imaging studies of the kidney.


Chemical & Pharmaceutical Bulletin | 1973

Whole-body Autoradiographic Study of Vitamin K Distribution in Rat

Tetsuya Konishi; Sigeo Baba; Hisao Sone


Archive | 1979

Cortisol radioimmunoassay method and cortisol derivatives useful therefor

Masaharu Kojima; Hisao Sone; Hiroshi Ogawa; Nobuhiko Nakazawa; Seiji Tachibana


Chemical & Pharmaceutical Bulletin | 1978

Relationships between Conformation of Antigen and Specificity of Antibody in Radioimmunoassay for Steroid Hormone. III. Highly Specific Cortisol-Antibody against 6α- and 6β-Hydroxycortisol 6-Hemisuccinate-Bovine Serum Albumin Conjugates

Hisao Sone; Masaharu Kojima


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1975

[Syntheses of 6-hydroxycortisol 6-hemisuccinate (author's transl)].

Hisao Sone; Masaharu Kojima; Hiroshi Ogawa


Chemical & Pharmaceutical Bulletin | 1978

Synthesis of Radioiodinated Analog of Oxazolidine-2,4-dione

Tadatoshi Yamaguchi; Kenichi Ichiki; Hisao Sone; Minoru Maeda; Masaharu Kojima


Yakugaku Zasshi-journal of The Pharmaceutical Society of Japan | 1976

[Relationships between conformation of antigen and specificity of antibody in radioimmunoassay for steroid hormone. II. Synthesis of 6-hydroxytestosterone 6-hemisuccinate-bovine serum albumin conjugates (author's transl)].

Hisao Sone; Hiroko Yoshimasu; Masaharu Kojima


Radioisotopes | 1979

[On renal excretion of sodium 4-iodo-5-methylpyrazole-3-carboxylate-131I (author's transl)].

Masaharu Kojima; Tomizono Y; Hisao Sone; Minoru Maeda


Archive | 1977

Radioimmunoassay of cortisol and novel cortisol derivatives useful therefor

Nobuhiko Nakazawa; Seiji Tachibana; Hisao Sone; Hiroshi Ogawa; Masaharu Kojima

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