Hisateru Aramaki
Japan Tobacco
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Publication
Featured researches published by Hisateru Aramaki.
Bioorganic & Medicinal Chemistry | 2013
Joshua P. Taygerly; Lawrence R. McGee; Steven M. Rubenstein; Jonathan B. Houze; Timothy D. Cushing; Yang Li; Alykhan Motani; Jin-Long Chen; Walter Frankmoelle; Guosen Ye; Marc Learned; Juan C. Jaen; Shichang Miao; Pieter B. M. W. M. Timmermans; Martin J. Thoolen; Patrick C. Kearney; John A. Flygare; Holger Beckmann; Jennifer Weiszmann; Michelle Lindstrom; Nigel Walker; Jinsong Liu; Donna H.T. Biermann; Zhulun Wang; Atsushi Hagiwara; Tetsuya Iida; Hisateru Aramaki; Yuki Kitao; Hisashi Shinkai; Noboru Furukawa
PPARγ is a member of the nuclear hormone receptor family and plays a key role in the regulation of glucose homeostasis. This Letter describes the discovery of a novel chemical class of diarylsulfonamide partial agonists that act as selective PPARγ modulators (SPPARγMs) and display a unique pharmacological profile compared to the thiazolidinedione (TZD) class of PPARγ full agonists. Herein we report the initial discovery of partial agonist 4 and the structure-activity relationship studies that led to the selection of clinical compound INT131 (3), a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
Journal of Medicinal Chemistry | 2006
Motohide Sato; Takahisa Motomura; Hisateru Aramaki; Takashi Matsuda; Masaki Yamashita; Yoshiharu Ito; Hiroshi Kawakami; Yuji Matsuzaki; Wataru Watanabe; Kazunobu Yamataka; Satoru Ikeda; Eiichi Kodama; Masao Matsuoka; Hisashi Shinkai
Journal of Medicinal Chemistry | 2009
Motohide Sato; Hiroshi Kawakami; Takahisa Motomura; Hisateru Aramaki; Takashi Matsuda; Masaki Yamashita; Yoshiharu Ito; Yuji Matsuzaki; Kazunobu Yamataka; Satoru Ikeda; Hisashi Shinkai
Archive | 2003
Motohide Satoh; Hiroshi Kawakami; Yoshiharu Itoh; Hisashi Shinkai; Takahisa Motomura; Hisateru Aramaki; Yuji Matsuzaki; Wataru Watanabe; Shuichi Wamaki
Archive | 2003
Motohide Satoh; Hiroshi Kawakami; Yoshiharu Itoh; Hisashi Shinkai; Takahisa Motomura; Hisateru Aramaki; Yuji Matsuzaki; Wataru Watanabe; Shuichi Wamaki
Archive | 2005
Motohide Satoh; Takashi Matsuda; Satoshi Okuda; Hiroshi Kawakami; Hisateru Aramaki; Hisashi Shinkai; Yuji Matsuzaki; Wataru Watanabe; Kazunobu Yamataka; Shinichi Kiyonari; Shuichi Wamaki; Mitsuru Takahashi; Naohito Yamada; Akemi Nagao
Archive | 2003
Motohide Satoh; Hiroshi Kawakami; Yoshiharu Itoh; Hisashi Shinkai; Takahisa Motomura; Hisateru Aramaki; Yuji Matsuzaki; Wataru Watanabe; Schuichi Wamaki
Archive | 2005
Motohide Satoh; Hisateru Aramaki; Hiroshi Nakamura; Masafumi Inoue; Hiroshi Kawakami; Hisashi Shinkai; Yuji Matsuzaki; Kazunobu Yamataka
Archive | 2007
Motohide Satoh; Hisateru Aramaki; Masaki Yamashita; Masafumi Inoue; Hiroshi Kawakami; Hisashi Shinkai; Hiroshi Nakamura; Yuji Matsuzaki; Shuichi Wamaki
Archive | 2007
Motohide Satoh; Hisateru Aramaki; Masaki Yamashita; Masafumi Inoue; Hiroshi Kawakami; Hisashi Shinkai; Hiroshi Nakamura; Yuji Matsuzaki; Shuichi Wamaki
