Homare Yamanaka

Development of a novel fungicide, cyflufenamid

Powdery mildew is one of the most serious crop diseases. Many fungicides have been developed and used for the control of powdery mildew. However, resistant strains of powdery mildew to some commercial fungicides have made disease control difficult. Cyflufenamid is a novel fungicide developed by Nippon Soda Co., Ltd. Cyflufenamid shows excellent control activities against powdery mildew of various plants and brown rot of stone fruits. It belongs to a new fungicide class, amidoximes. Its biological mode of action against pathogens is unique and differs from those of commercial fungicides. Cyflufenamid was first registrated in Japan in 2002. A mixture formulation of cyflufenamid with triflumizole was also developed to avoid the early appearance of resistant strains to the fungicide according to Nisso’s resistance risk management strategies. This paper describes the history of the discovery, synthesis, structure–activity relationships, biological activity, mode of action and safety of cyflufenamid.