Hong-Joo Kim

A new method of EMR: submucosal injection of a fibrinogen mixture

BACKGROUND The technical limitation associated with submucosal injection of normal saline solution during EMR is the relatively short duration of mucosal elevation. The clinical application of a new method of EMR with submucosal injection of a fibrinogen mixture was evaluated. METHODS Thirty-five early stage neoplastic gastric lesions were resected by EMR with submucosal injection of a fibrinogen mixture. The efficacy and clinical outcomes were analyzed. RESULTS Additional submucosal injection was not required for any of the 35 lesions to complete the EMR with submucosal injection of a fibrinogen mixture procedure. The rates of en bloc resection and complete resection were, respectively, 82.9% and 88.6%. The en bloc resection rate was significantly lower for lesions over 20 mm in diameter (60% vs. 92%; p<0.05) and for lesions on the lesser curvature or posterior wall of the stomach compared with those on the greater curvature or anterior wall (55.6% vs. 92.3%; p<0.05). The rate of complete resection also was dependent on the size and location of the lesions. There was no major EMR with submucosal injection of a fibrinogen mixture related complication including bleeding or perforation. CONCLUSIONS EMR with submucosal injection of a fibrinogen mixture is an easy, safe, and technically efficient method for complete EMR.

Serum adipocyte-specific fatty acid-binding protein is associated with nonalcoholic fatty liver disease in apparently healthy subjects

Adipocyte-specific fatty acid-binding protein (A-FABP) is a cytoplasmic protein that is expressed in adipocytes and is closely associated with insulin resistance, metabolic syndrome, and Type 2 diabetes. We investigated the relationship between A-FABP as a surrogate marker of metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) in apparently healthy subjects. We assessed clinical and biochemical metabolic parameters and measured serum levels of A-FABP, high-sensitivity C-reactive protein and tumor necrosis factor-α (TNF-α) in 494 subjects who were divided into two groups according to the presence of NAFLD by abdominal ultrasonography. All parameters associated with metabolic syndrome were significantly higher in patients with NAFLD (P<.001). A-FABP showed positive correlation with TNF-α, homeostasis model assessment index of insulin resistance (HOMA-IR), and metabolic syndrome (P<.001) when adjusted for age and sex. The odds ratio for the risk of NAFLD in the highest tertile of A-FABP compared with the lowest tertile was 7.36 (CI 3.80-14.27, P<.001) after adjustment for age and sex; 4.52 (CI 2.22-9.20, P<.001) after adjustment for age, sex, HOMA-IR and metabolic syndrome and 2.86 (CI 1.11-7.35, P<.05) after further adjustment for all metabolic parameters including TNF-α. The serum level of A-FABP was independently associated with NAFLD and showed significant correlation with TNF-α, HOMA-IR, and metabolic syndrome.

Large Volume CaMoO

Several scintillation CaMoO4 crystals with size up to 28times28times220 mm3 were grown by the Czochralski method. Their scintillation properties have been evaluated. Light yield of full size crystals measured with a XP2020 PMT is about 4% relative to a small reference CsI(Tl) crystal. Radio luminescence spectrum under gamma-excitation contains single emission peak with maximum at 520 nm. Optical transmission spectra contain a weak absorption band around 420 nm, which has almost no influence on scintillation light. This allows to produce even larger scintillation elements without deteriorating the light yield. Scintillation kinetics was measured under gamma- and alpha-particle excitation both in fast (2000 ns) and slow (200 mus) time scales. Fast components - 12 ns, (0.1%); 200 ns (0.5%) were detected along with slow - 3.8 mus (3.4%); 20 mus (96%) - components. Difference in fast component contribution under gamma and alpha excitation allows to implement pulse-shape discrimination of alpha-radioactive background coming from impurities in the crystals.

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Several scintillation CaMoO4 crystals with size up to 28times28times220 mm3 were grown by the Czochralski method. Their scintillation properties have been evaluated. Light yield of full size crystals measured with a XP2020 PMT is about 4% relative to a small reference CsI(Tl) crystal. Radio luminescence spectrum under gamma-excitation contains single emission peak with maximum at 520 nm. Optical transmission spectra contain a weak absorption band around 420 nm, which has almost no influence on scintillation light. This allows to produce even larger scintillation elements without deteriorating the light yield. Scintillation kinetics was measured under gamma- and alpha-particle excitation both in fast (2000 ns) and slow (200 mus) time scales. Fast components - 12 ns, (0.1%); 200 ns (0.5%) were detected along with slow - 3.8 mus (3.4%); 20 mus (96%) - components. Difference in fast component contribution under gamma and alpha excitation allows to implement pulse-shape discrimination of alpha-radioactive background coming from impurities in the crystals.

Scintillation Crystals

We designed a switchless event building farm for the Belle experiment at the KEKB e/sup +/e/sup -/ collider, as a replacement of the existing event builder and the online farm systems. In the new system, PCs are directly interconnected with multiple point-to-point Fast and Gigabit Ethernet connections. The PCs build the detector data in two steps to perform distributed event processing. We set up a test system and confirmed the event building performance meets our new requirements using a realistic prototype software. The system is being installed as scheduled using the summer shutdown time in 2001.

Large volume Ca_Mo_O-4 scintillation crystals

In order to test the existence of the sterile neutrino, NEOS experiment was performed from August 2015 to May 2016. The prompt energy spectrum from the inverse beta decay of electron antineutrino from a 2.8 GW

Switchless event building farm for the Belle data acquisition system

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Sterile neutrino search at the NEOS experiment

reactor was measured at 24 m distance. The number of measured IBD candidates is about 2000 per day during reactor-on period and a ratio of signal to background is about 22. The result shows no strong evidence of active-to-sterile neutrino. An exclusion-limit curve for 3+1 hypothesis is found at 90% CL. via shape-only analysis.

NEOS Detector for Reactor Antineutrinos

NEOS intends to understand the short-distance behavior of reactor neutrino oscillation. The detector has been obtaining about 2,000 inverse beta decay (IBD) events on daily base, since its performance was stabilized in September 2015. We present the geometry, the structure, and the current output of NEOS detector. The design of detector and the recipe of liquid scintillator mixture will be introduced, which were well set up enough to reduce the level of background. The signal-to-background ratio reached over 20. Including adjustment procedures for reconstruction, we will show the energy resolution of the detector and the energy calibration with GEANT4 simulation.

Improvement of Manufacturing Process for KUH by Applying new equipment

This paper contains a review of problems in the localized blade manufacturing process through KUH program and research for improvement of it. Contrary to development, mass production needs reliable process due to the long period of supply. The main process of blade manufacturing(Lay-Up, Curing) accepts new equipment(Robot, Heatmold) for improvement of it. And then, the evaluation is performed. Additionally, it is proven that blade which is made by the new process is suitable for mass production by conducting a performance test in the development phase.