Hong Keun Cho
Ewha Womans University
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Atherosclerosis | 2002
Hong Keun Cho; Gil-Ja Shin; Sung Kee Ryu; Yangsoo Jang; Stephen Day; Grace Stewart; Chris J. Packard; James Shepherd; Muriel J. Caslake
Small dense LDL is now emerging as an important risk factor for coronary artery disease. The amount of the LDL III has been reported to differ between ethnic groups. To investigate differences in the distribution of LDL subfractions between Korean and Scottish populations, we measured the plasma concentration and percent distribution of three major LDL subfractions in age-and sex-matched, middle aged, healthy 124 Korean and Scottish subjects (32 Korean men vs. 32 Scottish men; 30 Korean women vs. 30 Scottish women). Body mass index and waist circumference did not differ between the two ethnic groups. Total cholesterol and LDL cholesterol concentrations were higher in Scottish men compared with Korean men (P<0.01), while plasma triglyceride concentration was higher in Korean men and women (P<0.01 in men, P<0.05 in women). HDL cholesterol concentrations in both Korean men and women were lower than that of their Scottish counterparts (P<0.05 in men; P<0.001 in women). Korean men had lower concentrations of total LDL (242+/-65 vs. 325+/-122 mg/dl, P<0.01), LDL I (24+/-18 vs. 60+/-36 mg/dl, P<0.001) and LDL II (110+/-56 vs. 196+/-78 mg/dl, P<0.001). In contrast, LDL III concentration was markedly higher in Korean men (108+/-75 vs. 70+/-65 mg/dl, P<0.05). Likewise, the percent of LDL I (10.0+/-7.3 vs. 19.1+/-10.1%, P<0.001) and LDL II (47.2+/-20.7 vs. 60.1+/-10.9%, P<0.01) were lower in Korean men, while that of LDL III was higher (42.8+/-24.9 vs. 20.8+/-15.0%, P<0.001). In the female population, there were no differences in total LDL and LDL I concentrations between Korean and Scottish. LDL II concentration was lower in Korean women (106+/-53 vs. 151+/-57 mg/dl, P<0.01). Korean women showed a higher percent of LDL III (24.8+/-24.7 vs. 14.2+/-5.9%, P<0.05) and a lower LDL II (47.8+/-19.1 vs. 61.0+/-10.0%, P<0.01). Multiple linear regression revealed that plasma triglyceride concentration was the most important determinant of the LDL III subfraction concentration in Korean men and women and in Scottish men. In Korean men, the LDL III concentration rose linearly through the whole range of plasma triglyceride concentration, whereas in Scottish men, there was a threshold at 108 mg/dl triglyceride above which there was a positive association. Korean women showed the same pattern as Scottish men. We suggest that LDL concentrations and LDL subfraction distributions are regulated differently in these two ethnic groups. The different relationships between triglyceride and LDL III subfraction in Koreans versus Scots suggest that other factors, such as hepatic lipase or cholesteryl ester transfer protein may additionally play a role determining the LDL subfraction profile.
Nutrition Research | 2003
Min Jeong Shin; Eun Young Cho; Hyun-Young Park; Hong Keun Cho; Jong Ho Lee; Yangsoo Jang
Abstract We investigated whether apo E polymorphism contributes to the variations in blood lipid profile, apolipoprotein B and small dense LDL in 92 clinically healthy Korean subjects who traditionally consume a low fat and low cholesterol diet (40 males, 52 females, aged 24-60). Body weight, height, waist and hip circumference were measured. Body mass index (BMI) and waist to hip ratio (WHR) were calculated. Dietary intake was assessed by using a semi-quantitative Food Frequency Questionnaire. Alleles ϵ3, ϵ2 and ϵ4 showed relative frequencies of 72.8%, 7.6%, and 19.6%, respectively, in the subjects. In order to estimate the independent effects of alleles ϵ2 and ϵ4, as compared with ϵ3 homozygosity, on lipid and apolipoprotein parameters, multiple linear regression was performed after adjustment for confounding variables such as age, gender, BMI, WHR, smoking and alcohol consumption. Apo E polymorphism was associated with variations in the serum concentrations of LDL-cholesterol, apolipoprotein B and concentration of LDLIII (d 1.044 – 1.063 g/ml), and was higher in the allele ϵ4 than ϵ3 homozygosity. Moreover, the allele ϵ4 significantly increased the concentration of LDLIII even after adjustment for the serum concentration of triacylglycerol. The allele ϵ2 did not show any significant effects on lipid or apolipoprotein concentrations. Our results showed that the apo E4 isoform was related to higher levels of LDL-cholesterol and small dense LDL in Koreans who are exposed to a low fat, carbohydrate rich diet.
Molecules and Cells | 2004
Bo Hee Shin; Seung-Hyuk Choi; Eun Young Cho; Min Jeong Shin; Ki Chul Hwang; Hong Keun Cho; Ji Hyung Chung; Yangsoo Jang
European Journal of Pharmacology | 2004
Kyung Hye Lee; So Yeon Lim; Seok-Min Kang; Dae Hyeok Kim; Hong Keun Cho; Ji Hyung Chung; Hyuck Moon Kwon; Kwang Hoe Chung; Hakbae Lee; Yangsoo Jang; Ki Chul Hwang
Korean Circulation Journal | 2004
Eun Young Cho; Soo Jin Bae; Hong Keun Cho; Young Guk Ko; Hyun-Young Park; Jong Ho Lee; Yangsoo Jang
Korean Circulation Journal | 2000
Jeong Un Shin; Hong Keun Cho; Mi Seung Shin
Korean Circulation Journal | 1999
Hae Jin Lee; Gil-Ja Shin; Si Hoon Park; Hong Keun Cho
Korean Circulation Journal | 2001
Seong Hee Jeon; Young Sook Lee; Ji Eun Chang; Hong Keun Cho; Ick Mo Chung; Seong Hoon Park; Gil Ja Shin; Si Hoon Park
Nutritional sciences | 2003
Hong Keun Cho; Yangsoo Jang; Eun Young Cho; Hyun-Young Park; Hakbae Lee; Jong Eun Lee
Korean Circulation Journal | 1999
Hwa Jeong Kim; Hong Keun Cho; Wun Syub Han; Jae Ho Ahn