Hong Ra

70 Diagnostic value of serum B-type natriuretic peptide in the diagnosis of congestive heart failure in patients with impaired renal function - do we need a higher cutoff?

regression, and t student test were performed. Results: LogBNP was useful in distinguishing patients with CHF from patients without CHF (AUC=73%, 95%CI, 60% to 87%, p<0.001) in patients with eGFR between 30-90 ml/min/1.73m 2 ; mean BNP was 1143pg/ml in the CHF group vs. 531pg/ml in no CHF (p=0.003). However, logBNP could not distinguish CHF patients from patients without CHF in the group with eGFR between 15-29 ml/min/1.73m 2 (AUC=52%, 95%CI, 6% to 98%, p=0.68). Conclusions: In patients with mild to moderate renal dysfunction, serum BNP may still provide useful diagnostic information if the cutoff is higher (500 pg/ml). In patients with severe renal dysfunction (eGFR <15), BNP is not able to differentiate patients with congestion.