Hong-Ru Lin

A Novel In-Situ-Gelling Liquid Suppository for Site-Targeting Delivery of Anti-Colorectal Cancer Drugs

In order to avoid anti-cancer drugs undergoing a first-pass effect and reduce their toxicity, and to solve conventional suppositories defects, we developed an in-situ-gelling and injectable Pluronic–poly(acrylic acid) (Pluronic–PAA) liquid suppository, which could gel fast in the physiological state and had suitable gel strength and bioadhesive force. The liquid suppositories were inserted into the rectum of rabbits without difficulty and leakage, and retained in the rectum for at least 6 h and while releasing the drug. The toxicity and cytotoxic tests indicated that Pluronic and PAA were non-toxic materials and could inhibit colon cancer cells when oxaliplatin was incorporated. C max and AUC0→12h values of oxaliplatin after rectal administration of a oxaliplatin suppository were higher than those for an oxaliplatin solution administered orally. These results suggest that an in-situ-gelling and injectable liquid suppository for humans can be further developed as a more convenient and effective rectal dosage form.

NOVEL STABLE HUMIDITY LAYERS PREPARED BY SURFACE GRAFT POLYMERIZATION OF ANIONIC MONOMERS MIXING WITH PHENOL-FORMALDEHYDE

In this study, humidity-sensitive polymer layer containing phenol-formaldehyde resin prepared by spinning coating on the comb-shape type electrode followed by UV-graft polymerization of soluble monomer was performed to improve the sensitivity. In this investigation, grafting of P-styrenesulfonic acid sodium salt (NaSS) treated with hexamethyldisilazan (HMDSZ) plasma and acrylic acid (AAc) followed by isopropanol (IPA) plasma were used as monomer for UV surface graft polymerization. Results show the first one adding different ratio of phenol-formaldehyde resin. This type of sensor has linear response with %RH, and high sensitivity (impedance from 106 to 103). The impedance of second type of sensor was linear response with %RH, impedance varies from 107 to 105.

Effect of Plasma Gas Flow Direction on Hydrophilicity of Polymer by Small Zone Cold Plasma Treatment and Hydrophobic Plasma Treatment

Plasma treatment is the most popular surface modification process of polymers. A small cold plasma zone treatment is an important modification technique in modern industry. In this study, the effect of gas flow direction on plasma treatment was investigated. In order to decrease the plasma zone area, we added a separate cylinder to surround the upper electrode. The separate cylinder is effective in limiting the plasma discharge area, and we could find a light and dark area in the vacuum chamber. After O2 plasma treatment, the result shows that only PP nonwoven in the discharge area became hydrophilic, but the other position away from the plasma zone was not affected. The water adsorption of PP nonwoven increased from 34.8% to 537.4%. When the sample is further from the plasma zone, near the up stream of gas flow, the surface property is less hydrophilic. The water contact angle analysis of PS and glass shows the same results as those of PP nonwoven. But PET in plasma zone or dark zone (plasma zone: 75° to 31°, dark zone: 75° to 52°) both show hydrophilic property. The wettability effect in the dark zone may be due to the UV-light irradiation in the process of plasma excitation.

FABRICATION OF QCM TYPE SMOTHER DETECTION SENSOR BY PLASMA POLYMERIZING SnOx ORGANIC-LIKE FILMS AND SPIN COATING WITH POLY ETHYLENE GLYCOL

Quartz crystal microbalances (QCM) are transducers for chemical and biochemical sensing. The oscillation frequency of QCM is affected by the adsorbed mass on the surface. In this work, a new room temperature type gas sensor device fabricated by organically hybridized plasma deposition of tetramethyltin (TMT) and oxygen. Post treatment with poly ethylene glycol (PEG) was developed to detect the ambient environmental smother, and the responses of the fabricated sensor to smother detection were investigated. SnOxCy thin films on the sensor electrodes were obtained by plasma deposition from TMT and O2 gas mixtures at room temperature. A spin coating post treatment on the SnOxCy thin films turns into hydrophilic property. The response of the QCM sensor to the smother detection shows a frequency drop during the burning of candle and has good detection sensitivity with Δf equal to 2400 Hz. Repeated smother testing with the QCM type smother detection sensor also indicates the stability of the fabricated sensor.