Hong-Yun Guo

A simple three-component synthesis of spiro-pyran derivatives

A series of spiro-pyran derivatives have been synthesised by a three-component reaction of ninhydrin or acenaphthenequinone, malononitrile and 1,3-dicarbonyl compounds such as cyclohexane-1,3-dione, dimedone and barbituaric acid in ethanol with NaHCO3 as the catalyst. This method has the advantages of easy work-up, mild reaction condition, high yields and it is cheap.

A novel synthesis of selenosulfides from diselenides by samarium diiodide

Diselenides were reduced by samarium diiodide in tetrahydrofuran (THF) to produce samarium selenolate. This selenolate anion reacted smoothly with sodium alkyl thiosulfates and phenylsulfenyl chloride to give selenosulfides in moderate to good yields.

Ionic liquid catalyzed one-pot synthesis of spiropyran derivatives via three-component reaction in water

Abstract The ionic liquid [H3N+CH2CH2OH][CH3COO-] (HEAA) catalyzes a three-component, one-pot condensation of malononitrile/ethyl cyanoacetate, 1,3-dicarbonyl compound/enol, and quinone or ninhydrin in water to afford a spiropyran derivative. This method has advantages of mild reaction conditions, short reaction time, and environmental friendliness.

Solvent-free and ionic liquid catalysed three-component method synthesis of spiro-2-amino-4 H -pyrans derivatives

In the absence of any solvent, a series of spiro-2-amino-4H-pyrans derivatives were synthesised via the three component reaction of malononitrile and α-methylencarbonyl compounds/enol with 9,10-phenanthroquinone or ace-naphthenequinone using 1-butyl-3-methylimidazolium hydroxide ([bmim][OH]) as a basic ionic liquid catalyst. This method has some distinct advantages such as mild reaction conditions, short reaction time and is environmentally friendly.

One-pot synthesis of thiazolo[3,2-α]pyridine derivatives catalysed by ionic liquids

A green method for the synthesis of thiazolo[3,2-α]pyridine derivatives via the coupling of malononitrile, an aryl aldehyde and methyl thioglycolate in an ionic liquid has been developed. The advantages of this protocol are that it is non-toxic, no by-products are formed, short reaction times are required and high yields are obtained. Thiazolo [3,2-α]pyridines have important biological and medical applications.

A convenient method for the reductive desulfonylation of some sulfones by the Sm/HOAc system

Metallic samarium can be used in desulfonylation in the presence of glacial acetic acid. The reaction is illustrated here for nine substrates, which include α-phenylsulfonyl cinnamonitriles, β-ketosulfones and phenylsulfonyl cycloheptane.

Basic ionic liquid HEAA catalysed one-pot synthesis of novel 2-amino-3-phenylsulfonyl-4H-pyrans derivatives

An efficient preparation of novel 2-amino-3-phenylsulfonyl-4H-pyrans derivatives is reported by the condensation of aromatic aldehydes, dimedone and phenylsulfonylacetonitrile in the presence of 2-hydroxyethyl ammonium acetate [H3N+CH2CH2OH] [CH3COO-] (HEAA) as suitable and efficient catalyst. This method offers some distinct advantages such as short reaction time, high yields, and simple procedure.

Stereoselective Synthesis of (E)-Cinnamonitriles with the SmI2/THF/MeOH System

α-Phenylsulfonylcinnamonitriles are readily reduced by SmI2/THF/MeOH to give the corresponding (E)-cinnamonitriles in good yields under mild conditions.

Convenient one-pot synthesis of α-selenonitriles, α-selenoesters and asymmetrical selenides by a Sm/ZnCl 2 system in DMF-H 2 O

α-Selenonitriles, α-selenoesters, and asymmetrical selenides can be readily obtained from the one-pot reaction of diselenides and active organic halides by a Sm/ZnCl2 system in DMF-H2O.

A novel method for pinacolic coupling of aromatic aldehydes and ketones with a Sm-ZnCl 2 system

Sm–ZnCl2-system-mediated reductive coupling of aromatic aldehydes and ketones in THF–H2O at room temperature affords the corresponding pinacols in moderate to good yields.