Hongmin Su

Target synthesis of a novel porous aromatic framework and its highly selective separation of CO2/CH4

A novel porous aromatic framework based on tetra-(4-anilyl)-methane and cyanuric chloride has been designed and synthesized successfully, which possesses permanent porosity and high selectivity of CO2 towards CH4.

Syntheses, structures and luminescence properties of three metal–organic frameworks based on 5-(4-(2H-tetrazol-5-yl)phenoxy)isophthalic acid

Three metal–organic frameworks (MOFs), namely [Zn2(TPIA)(OH)(H2O)]·H2O (JUC-114), [Cd2(TPIA)(OH)(H2O)2]·H2O (JUC-115), and [Co2(TPIA)(OH)(H2O)2]·H2O (JUC-116) (JUC = Jilin University China), based on a new ligand, 5-(4-(2H-tetrazol-5-yl)phenoxy)isophthalic acid (H3TPIA), were synthesized under hydrothermal conditions and characterized by single crystal X-ray diffraction, elemental analysis, IR spectroscopy, TGA analysis and powder X-ray diffraction. JUC-114, JUC-115 and JUC-116 all possess 3D frameworks with (4,8)-connected fluorite (flu) topology based on similar tetranuclear metal centers as secondary building unit (SBU). Furthermore, the luminescence of the ligand H3TPIA and compounds was measured at room temperature.

Four new metal–organic frameworks based on bi-, tetra-, penta-, and hexa-nuclear clusters derived from 5-(phenyldiazenyl)isophthalic acid: syntheses, structures and properties

Four new metal–organic frameworks (MOFs), namely, [Cu(PDIA)(DMA)]n (JUC-126), [Mn4(PDIA)4(DMF)6]n·nDMF·2nH2O (JUC-127), [Zn23(PDIA)18(μ4-O)2(μ3-OH)6DMA6]n·10nDMA·6nH2O (JUC-128), [Co3(PDIA)2(HCOO)(μ3-OH)(H2O)(DMA)2]n·nDMA·nH2O (JUC-129) (JUC = Jilin University, China), based on a new rigid ligand 5-(phenyldiazenyl)isophthalic acid (H2PDIA) with azobenzene were synthesized under solvothermal conditions. The ligand is connected to different metals to form bi-, tetra-, penta- and hexa-nuclear cores with distinctive coordination modes to generate different structures. Moreover, π–π stacking interactions between arene cores of the ligands also exist to affect the structural assembly process. JUC-126 displays a three-dimensional (3D) NbO topology with the point symbol (64·82) based on Cu2(COO)4 as secondary building units (SBUs), JUC-127 shows a two-dimensional (2D) sql topology with the point symbol (44·62) based on Mn2(COO)4 as SBUs, JUC-128 has a new 3D topology with the point symbol (33·46·56)2(36·48·510·64)3 based on Zn4O(COO)6 and Zn5(μ3-OH)2(COO)8 as SBUs and JUC-129 exhibits a 2D sql topology with the point symbol (44·62) based on Co6(μ3-OH)2(COO)10 as SBUs. In addition, JUC-126, JUC-128 and JUC-129 are achiral frameworks; however, JUC-127 shows a chiral framework from an achiral ligand. Furthermore, the luminescent property of JUC-128 and the magnetic properties of JUC-127 and JUC-129 have been studied and discussed.

Dissolution and pharmacokinetic properties of two paliperidone cocrystals with 4-hydroxybenzoic and 4-aminobenzoic acid

The pharmaceutical cocrystal approach can be used to modify the properties of paliperidone. We report here two novel cocrystals, paliperidone 4-hydroxybenzoic acid cocrystal (1, 1:1, w/w) and paliperidone 4-aminobenzoic acid cocrystal (2, 1:1, w/w), with CCDC numbers of 855981 and 948923, which were constructed using paliperidone with 4-hydroxybenzoic acid and 4-aminobenzoic acid, respectively. The experimental results of the dissolution studies revealed that both 1 and 2 showed much faster dissolution rates than the original active pharmaceutical ingredient (API) in simulated gastric fluid media (pH = 1.2). The pharmacokinetic (PK) studies of 1, 2 and the original API were conducted using beagle dogs. 1 has a slightly higher maximal serum concentration, and both of the cocrystals presented considerably faster absorption rates after a single-dose oral administration to beagle dogs compared to the original API. Observed improvements suggested their potential application to the treatment of acute schizophrenia.